Gordienko S M
Zh Mikrobiol Epidemiol Immunobiol. 1985 Jul(7):83-8.
Experiments on mice of different strains have demonstrated that sensitization with BCG vaccine slightly increases resistance to infection with Francisella tularensis, Escherichia coli 819 and influenza A2 virus in mice of those strains which are capable of developing a high level of delayed hypersensitivity (DH). On the contrary, sensitization with Staphylococcus aureus b-243 decreases this resistance. A sharp increase in resistance to infection has been achieved in sensitized animals receiving DH-inducing specific antigen (old tuberculin or staphylococcal phagolysate) 24 hours before inoculation. This increased resistance to infection is due mainly to the eliminating capacity of the reticuloendothelial system and not to the bactericidal factors of the serum. The level of sensitization and the manifestation of DH reaction have been found to be genetically determined and to govern the degree of activation of nonspecific immunity.
对不同品系小鼠进行的实验表明，用卡介苗致敏可使那些能够产生高水平迟发型超敏反应（DH）的品系小鼠对土拉弗朗西斯菌、大肠杆菌819和甲型流感病毒2感染的抵抗力略有增强。相反，用金黄色葡萄球菌b - 243致敏会降低这种抵抗力。在接种前24小时接受诱导DH的特异性抗原（旧结核菌素或葡萄球菌吞噬溶解物）的致敏动物中，对感染的抵抗力急剧增加。这种对感染抵抗力的增加主要归因于网状内皮系统的清除能力，而非血清的杀菌因子。已发现致敏水平和DH反应的表现由基因决定，并决定非特异性免疫的激活程度。
