Gordienko S M
Zh Mikrobiol Epidemiol Immunobiol. 1986 Apr(4):57-61.
The experiment on (BALB/cXC57BL)F1 mice, showing a high level of delayed hypersensitivity (DH) when sensitized with BCG vaccine and Staphylococcus aureus strain B-243, has demonstrated the influence of such sensitization and DH reaction induced by the injection of a specific antigen (old tuberculin or staphylococcal phagolysate) into the sensitized animals on the cytotoxicity of macrophages, natural killers (NK) and antibody-dependent killers (ADK). Sensitization with BCG vaccine alone results in an insignificant rise in the activity of these effector cells, and sensitization with S. aureus produces no changes at all. The pronounced activation of the cytotoxicity of macrophages, NK and, to a lesser extent, ADK has been observed in DH reaction induced by the injection of a specific antigen into the sensitized mice. In the course of DH reaction a rise in the activity of NK and ADK not only against tumor target cells, but also against microbial ones (Candida albicans and S. aureus) has been found to occur.
在用卡介苗和金黄色葡萄球菌B - 243菌株致敏时表现出高水平迟发型超敏反应（DH）的（BALB/cXC57BL）F1小鼠实验中，已证明这种致敏以及向致敏动物注射特定抗原（旧结核菌素或葡萄球菌吞噬溶酶体）所诱导的DH反应对巨噬细胞、自然杀伤细胞（NK）和抗体依赖性杀伤细胞（ADK）细胞毒性的影响。单独用卡介苗致敏会导致这些效应细胞的活性略有上升，而用金黄色葡萄球菌致敏则根本没有变化。在向致敏小鼠注射特定抗原所诱导的DH反应中，已观察到巨噬细胞、NK以及程度较轻的ADK的细胞毒性有明显激活。在DH反应过程中，已发现NK和ADK的活性不仅针对肿瘤靶细胞，而且针对微生物靶细胞（白色念珠菌和金黄色葡萄球菌）均有所上升。
