Gordienko S M
Zh Mikrobiol Epidemiol Immunobiol. 1986 May(5):77-82.
In vivo experiments on the infection of mice with influenza A virus and Francisella tularensis and in vitro experiments on the bactericidal activity of macrophages have demonstrated the conditions leading to the maximally pronounced activation of immunity by means of preparations inducing delayed hypersensitivity (DH). The following conditions have been determined: the presence of pronounced DH previously to the injection of old tuberculin (OT) and staphylococcal phagolysate (SP) used as challenge antigens, the specificity and peculiar features of the antigenic structure of the challenge agent, the time of its administration after the course of multiple sensitizing injections of BCG and staphylococci, the dosage of OT and SP and the scheme of their administration, the desirability of their local use. The time of the maximum activation of cell-mediated immunity after the injection of OT and SP to sensitized animals with a high level of DH and the duration of such activation have been established.
对甲型流感病毒和土拉弗朗西斯菌感染小鼠的体内实验以及对巨噬细胞杀菌活性的体外实验，已经证明了通过诱导迟发型超敏反应（DH）的制剂实现免疫最大程度显著激活的条件。已确定以下条件：在注射用作激发抗原的旧结核菌素（OT）和葡萄球菌吞噬溶解物（SP）之前存在明显的DH、激发剂抗原结构的特异性和特点、在多次注射卡介苗和葡萄球菌进行致敏疗程后给予激发剂的时间、OT和SP的剂量及其给药方案、局部使用它们的可取性。已经确定了向具有高水平DH的致敏动物注射OT和SP后细胞介导免疫最大激活的时间以及这种激活的持续时间。
