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理解长期使用加巴喷丁的情况增加:一项关于开处方案意图的全国养老院临床医生调查。

Understanding Long-Stay Gabapentin Use Increases: A National Nursing Home Clinician Survey on Prescribing Intent.

机构信息

Department of Family Medicine and Population Health, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

Shenandoah Valley Family Practice Residency, Front Royal, Virginia, USA.

出版信息

Clin Gerontol. 2024 Oct-Dec;47(5):789-799. doi: 10.1080/07317115.2024.2379974. Epub 2024 Jul 17.

Abstract

OBJECTIVES

Explore the indications for long-stay gabapentin use and elucidate the factors spurring the rapid increase in gabapentin prescribing in nursing homes (NHs).

METHODS

National cross-sectional survey of NH prescribers distributed anonymously using SurveyMonkey. Sampling for convenience was obtained through crowdsourcing, leveraging collaborations with NH clinician organizations. Developed by a multidisciplinary team, pilot data/existing literature informed survey content.

RESULTS

A total of 131 surveys completed. Participants: 71% white, 52% female, 71% physicians. Off-label gabapentin prescribing was ubiquitous. Nearly every clinician used gabapentin for neuropathic pain, most for any form of pain. Many clinicians also prescribe gabapentin to moderate psychiatric symptoms and behaviors. Clinicians' prescribing was influenced by opioid, antipsychotic, and anxiolytic reduction policies because gabapentin was perceived as an unmonitored and safer alternative.

CONCLUSIONS

Off-label gabapentin increases are closely linked to opioid reduction efforts as more NH clinicians utilize gabapentin as an unmonitored opioid alternative. Our results highlight, however, the less recognized significance of long-stay prescribing for psychiatric symptoms and the similar contribution of psychotropic reduction initiatives, a phenomenon warranting further scrutiny.

CLINICAL IMPLICATIONS

Clinicians perceive gabapentin as safer than the drugs it is replacing. Whether this is true remains unclear; the individual- and population-level risks of increased gabapentin use are largely unknown.

摘要

目的

探讨长期使用加巴喷丁的适应证,并阐明促使养老院(NH)中加巴喷丁处方快速增加的因素。

方法

使用 SurveyMonkey 对 NH 处方者进行匿名全国性横断面调查。通过众包获得方便抽样,利用与 NH 临床医生组织的合作关系。由多学科团队开发,试点数据/现有文献为调查内容提供了信息。

结果

共完成 131 份调查。参与者:71%为白人,52%为女性,71%为医生。加巴喷丁的标签外处方普遍存在。几乎每个临床医生都将加巴喷丁用于治疗神经性疼痛,大多数用于任何形式的疼痛。许多临床医生还将加巴喷丁用于治疗中度精神症状和行为。临床医生的处方受到阿片类药物、抗精神病药物和抗焦虑药物减少政策的影响,因为加巴喷丁被认为是一种未经监测且更安全的替代药物。

结论

标签外加巴喷丁的增加与阿片类药物减少努力密切相关,因为越来越多的 NH 临床医生将加巴喷丁用作未经监测的阿片类药物替代品。然而,我们的研究结果突出了长期处方用于治疗精神症状的意义,以及精神药物减少计划的类似贡献,这一现象值得进一步研究。

临床意义

临床医生认为加巴喷丁比它所替代的药物更安全。这是否属实尚不清楚;增加加巴喷丁使用的个体和人群风险在很大程度上尚不清楚。

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