Kırklareli Training and Research Hospital - Department of Cardiology, Kırklareli - Turquia.
Kırklareli University Medical School - Kırklareli Training and Research Hospital - Department of Internal Medicine, Kırklareli - Turquia.
Arq Bras Cardiol. 2024 Jun;121(6):e20230680. doi: 10.36660/abc.20230680.
Atrial fibrillation (AF) burden is defined as the proportion of time the patient remains in AF over a given period of time; thus, it is theoretically highest in permanent AF and lowest in paroxysmal AF. Inflammation is associated with the initiation and maintenance of AF. However, the relationship between systemic immune-inflammation index (SII) and AF burden is unknown.
In the present study, we investigated the relationship between SII and AF burden.
The present study is a cross-sectional analysis of 453 patients (252 females and 201 males, aged 44 to 94 years) with AF (138 with paroxysmal AF and 315 with permanent AF) who visited the cardiology outpatient clinic between October 2022 and June 2023. SII was calculated as (neutrophils × platelets/lymphocytes). The predictive role of SII and other inflammatory markers in the likelihood of AF pattern was evaluated by logistic regression analyses, and p value < 0.05 was considered statistically significant.
Age, diastolic blood pressure, heart rate, diabetes mellitus, neutrophil, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, SII, C-reactive protein, red blood cell distribution width, hemoglobin A1c, and left atrial diameter were significantly higher in the permanent AF group. According to the logistic regression analysis, age (p = 0.038), diabetes mellitus (p = 0.024), red blood cell distribution width (p = 0.023), C-reactive protein (p = 0.010), SII (p = 0.001), and left atrial diameter (p < 0.001) significantly contributed to the prediction of the likelihood of permanent AF.
SII is independently associated with the AF burden. Prospective studies are needed to determine whether SII may be useful in identifying patients at high risk for AF progression.
房颤（AF）负荷定义为患者在给定时间段内处于 AF 状态的时间比例；因此，在永久性 AF 中最高，在阵发性 AF 中最低。炎症与 AF 的发生和维持有关。然而，系统免疫炎症指数（SII）与 AF 负荷之间的关系尚不清楚。
本研究旨在探讨 SII 与 AF 负荷之间的关系。
本研究为横断面分析，纳入 2022 年 10 月至 2023 年 6 月期间心内科门诊就诊的 453 例 AF 患者（女性 252 例，男性 201 例，年龄 44~94 岁），其中阵发性 AF 138 例，永久性 AF 315 例。SII 计算方法为（中性粒细胞×血小板/淋巴细胞）。通过逻辑回归分析评估 SII 和其他炎症标志物对 AF 模式可能性的预测作用，p 值<0.05 为统计学显著。
永久性 AF 组患者年龄、舒张压、心率、糖尿病、中性粒细胞、血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值、SII、C 反应蛋白、红细胞分布宽度、血红蛋白 A1c 和左心房直径均显著升高。根据逻辑回归分析，年龄（p=0.038）、糖尿病（p=0.024）、红细胞分布宽度（p=0.023）、C 反应蛋白（p=0.010）、SII（p=0.001）和左心房直径（p<0.001）显著有助于预测永久性 AF 的可能性。
SII 与 AF 负荷独立相关。需要前瞻性研究来确定 SII 是否可用于识别 AF 进展风险较高的患者。
