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机器人辅助前列腺根治术后长期尿失禁的临床特征及预测因素:倾向匹配分析。

Clinical characteristics and predictors of long-term postoperative urinary incontinence in patients treated with robot-assisted radical prostatectomy: A propensity-matched analysis.

机构信息

Department of Urology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

出版信息

Int J Urol. 2024 Oct;31(10):1145-1152. doi: 10.1111/iju.15533. Epub 2024 Jul 17.

Abstract

OBJECTIVES

This study aimed to elucidate the clinical characteristics and predictors of long-term postoperative urinary incontinence (PUI) after robot-assisted radical prostatectomy (RARP).

METHODS

This study included patients who underwent RARP at our institution and were stratified into PUI (≥1 pad/day) and continence (0 pad/day) groups at 60 months after RARP. A propensity score-matched analysis with multiple preoperative urinary status (Expanded Prostate Cancer Index Composite urinary subdomains, total International Prostate Symptom Score (IPSS), and IPSS-quality of life scores) was performed to match preoperative urinary status in these groups. Serial changes in urinary status and treatment satisfaction preoperatively and until 60 months after RARP were compared, and predictors of long-term PUI were assessed using multivariate logistic regression analysis.

RESULTS

A total of 228 patients were included in the PUI and continence groups (114 patients each). Although no significant difference in preoperative urinary status was observed between the two groups, the postoperative urinary status significantly worsened overall in the PUI group than in the continence group. Treatment satisfaction was also significantly lower in the PUI group than in the continence group from 12 to 60 months postoperatively. Multivariate logistic regression analysis revealed that age (≥70 years) and biochemical recurrence (BCR) were significant predictors of the long-term PUI group (p < 0.05).

CONCLUSIONS

Patients with long-term PUI had poor overall postoperative urinary status and lower treatment satisfaction than the continence group. Considering the age and risk of BCR is important for predicting long-term PUI when performing RARP.

摘要

目的

本研究旨在阐明机器人辅助前列腺根治性切除术(RARP)后长期术后尿失禁(PUI)的临床特征和预测因素。

方法

本研究纳入了在我院接受 RARP 治疗的患者,并在 RARP 后 60 个月将其分为 PUI(≥1 片/天)和控尿(0 片/天)组。采用倾向性评分匹配分析(Expanded Prostate Cancer Index Composite 尿亚域、总国际前列腺症状评分(IPSS)和 IPSS 生活质量评分)对两组患者的术前尿状态进行匹配。比较术前和 RARP 后 60 个月的尿状态变化和治疗满意度,并采用多变量逻辑回归分析评估长期 PUI 的预测因素。

结果

共纳入 228 例 PUI 和控尿组患者(每组 114 例)。虽然两组患者的术前尿状态无显著差异,但 PUI 组患者的术后尿状态总体上较控尿组恶化。从术后 12 个月到 60 个月,PUI 组的治疗满意度也明显低于控尿组。多变量逻辑回归分析显示,年龄(≥70 岁)和生化复发(BCR)是长期 PUI 组的显著预测因素(p<0.05)。

结论

与控尿组相比,长期 PUI 患者的整体术后尿状态较差,治疗满意度较低。在进行 RARP 时,考虑年龄和 BCR 风险对于预测长期 PUI 很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be4b/11524109/c1b354f33786/IJU-31-1145-g002.jpg

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