Ren Jiaoyu, Yang Xinyu
School of Chemical Engineering & Technology, China University of Mining and Technology, Xuzhou, Jiangsu 221116, PR China.
Langmuir. 2024 Jul 17. doi: 10.1021/acs.langmuir.4c01539.
In this study, we present a novel system consisting of nanomotors and a hydrogel. Calcium carbonate nanomotors are prepared using layer-by-layer self-assembly technology with calcium carbonate nanoparticles as the core and catalase (CAT) and polydopamine (PDA) as the shell. Calcium carbonate nanomotors were loaded into a Schiff base hydrogel to synthesize the CaCO@NM-hydrogel system. A nanomotor is a device that works on the nanoscale to convert some form of energy to mechanical energy. The motion speed of the system in 5.0 mM HO aqueous solution under near-infrared light (NIR) irradiation with a power density of 1.8 W/cm is 13.6 μm/s. The addition of CaCO@NM further promotes gelation and improves the mechanical properties. The energy storage modulus increases to 4.0 × 10 Pa, which is 50 times higher. Schiff base hydrogels form dynamic reversible chemical bonds due to inter- and intramolecular hydrogen bonding. They also have good self-healing properties, as observed by measuring the energy storage modulus versus the loss modulus at 1 versus 10 kHz. The results show that the system significantly inhibited the growth of both Gram-positive bacteria, , and Gram-negative bacteria, , after 48 h, with an inhibition rate of nearly 95%. These findings provide a basis for further research and potential applications of the system in wound dressings.
在本研究中，我们展示了一种由纳米马达和水凝胶组成的新型系统。碳酸钙纳米马达采用层层自组装技术制备，以碳酸钙纳米颗粒为核心，过氧化氢酶（CAT）和聚多巴胺（PDA）为外壳。将碳酸钙纳米马达负载到席夫碱水凝胶中，合成了CaCO@NM-水凝胶系统。纳米马达是一种在纳米尺度上工作，将某种形式的能量转化为机械能的装置。该系统在功率密度为1.8W/cm的近红外光（NIR）照射下，在5.0mM H₂O₂水溶液中的运动速度为13.6μm/s。CaCO@NM的加入进一步促进了凝胶化并改善了机械性能。储能模量增加到4.0×10⁵Pa，高出50倍。席夫碱水凝胶由于分子间和分子内的氢键形成动态可逆化学键。通过在1kHz和10kHz下测量储能模量与损耗模量，也观察到它们具有良好的自愈性能。结果表明，该系统在48小时后显著抑制了革兰氏阳性菌和革兰氏阴性菌 的生长，抑制率近95%。这些发现为该系统在伤口敷料中的进一步研究和潜在应用提供了依据。
