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撤回声明:微小RNA-23b的下调通过上调大鼠中的MDM4经p53信号通路预防缺血-再灌注损伤

RETRACTION: Downregulation of microRNA-23b Protects Against Ischemia-Reperfusion Injury via p53 Signaling Pathway by Upregulating MDM4 in Rats.

出版信息

J Cell Biochem. 2024 Oct;125(10):e30622. doi: 10.1002/jcb.30622. Epub 2024 Jul 17.

DOI:10.1002/jcb.30622
PMID:39016548
Abstract

Z. Zhao, J.-Z. Guan, M. Wu, G.-H. Lai, and Z.-L. Zhu. Downregulation of microRNA-23b Protects Against Ischemia-Reperfusion Injury via p53 Signaling Pathway by Upregulating MDM4 in Rats. Journal of Cellular Biochemistry 120, no. 3 (2019): 4599-4612, https://doi.org/10.1002/jcb.27748. The above article, published online on 9 December 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties on the data presented in the article. Several flaws and inconsistencies between results presented and experimental methods described were found. Furthermore, the same sample used to depict the immunofluorescence staining in Figure 5B was found to have been used in a different scientific context in a previous publication from a different author group. Thus, the editors consider the conclusions of this article to be invalid.

摘要

赵Z、关J-Z、吴M、赖G-H、朱Z-L。微小RNA-23b的下调通过上调大鼠体内的MDM4,经由p53信号通路预防缺血再灌注损伤。《细胞生物化学杂志》120卷,第3期(2019年):4599 - 4612页,https://doi.org/10.1002/jcb.27748 。上述文章于2018年12月9日在线发表于威利在线图书馆(wileyonlinelibrary.com),已根据作者、期刊主编克里斯蒂安·贝尔以及威利期刊有限责任公司之间的协议撤回。撤回是由于第三方对文章中所呈现的数据提出的担忧。发现了所呈现结果与所描述实验方法之间的若干缺陷和不一致之处。此外,用于图5B中免疫荧光染色描绘的同一样本,被发现在来自不同作者团队的先前出版物中用于了不同的科学背景。因此,编辑们认为本文的结论无效。

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