Zhang Ni, Liang Dongyi, Shen Yang, She Xiaoyi, Jin Chongjun
State Key Laboratory of Optoelectronic Materials and Technologies, Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China.
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China.
ACS Appl Mater Interfaces. 2024 Jul 31;16(30):39917-39926. doi: 10.1021/acsami.4c09535. Epub 2024 Jul 17.
We proposed and demonstrated highly sensitive hybrid surface-enhanced Raman scattering (SERS) substrates, which are grating-integrated gold nanograsses (GIGN) that are tip-selectively encapsulated by ZIF-8 nanospheres (GIGN/tip-ZIF). This unique structure is realized through the tip-selective modification of GIGN by polyvinylpyrrolidone (PVP), and then, the tips of the GIGN were encapsulated by ZIF-8 nanospheres. The ZIF-8 nanospheres can adsorb analyte molecules, resulting in the spatial overlap between the analyte molecules and the "hotspots" on the tips of GIGN. Such a unique GIGN/tip-ZIF hybrid SERS substrate exhibits high sensitivity and quantitative detection ability. The detection limits can reach as low as 10 M, and the relative standard deviation is 5.59% for 4-aminothiophenol (4-ATP). In a wide range of concentrations from 10 to 10 M, the SERS intensity and concentration relationship can be fitted as a sigmoidal curve with = 0.988. These indicate that the GIGN/tip-ZIF hybrid SERS substrates have broad applications in detecting toxic and harmful substances in food safety, disease diagnosis, and environmental monitoring.
我们提出并展示了高灵敏度的混合表面增强拉曼散射（SERS）基底，即光栅集成金纳米草（GIGN），其尖端被ZIF-8纳米球选择性包覆（GIGN/尖端-ZIF）。这种独特的结构是通过用聚乙烯吡咯烷酮（PVP）对GIGN进行尖端选择性修饰来实现的，然后，GIGN的尖端被ZIF-8纳米球包覆。ZIF-8纳米球可以吸附分析物分子，导致分析物分子与GIGN尖端的“热点”之间产生空间重叠。这种独特的GIGN/尖端-ZIF混合SERS基底具有高灵敏度和定量检测能力。检测限可低至10⁻¹² M，对4-氨基硫酚（4-ATP）的相对标准偏差为5.59%。在10⁻¹²至10⁻⁶ M的宽浓度范围内，SERS强度与浓度关系可拟合为一条相关系数为0.988的S形曲线。这些表明GIGN/尖端-ZIF混合SERS基底在食品安全、疾病诊断和环境监测中检测有毒有害物质方面具有广泛应用。
