Denaro A, Martucci N, Ruggieri S, Manna V, Agnoli A
Acta Psychiatr Scand Suppl. 1985;320:20-5. doi: 10.1111/j.1600-0447.1985.tb08070.x.
The efficacies of an 2-agonist clonidine and an 2-antagonist mianserin were compared in two treatment groups, common migraine and tension headache sufferers. Forty patients entered this double-blind placebo-controlled study. Placebo, clonidine 0.150 mg, and mianserin 30 mg were each administered for 90 day periods. Headaches were induced by intravenous doses of histamine dihydrochloride. The histamine threshold in the common migraine group was significantly lower than in the tension headache group. In the common migraine group, mianserin decreased headache frequency. In the tension headache group, at 90 days mianserin significantly decreased headache intensity and headache frequency. Clonidine significantly decreased headache intensity at 90 days in the common migraine group. At 90 days, mianserin had significantly reduced the Hamilton Depression Rating Scale (HDRS) mean total score, (in the tension headache group), HDRS mean anxiety cluster scores (in both groups), and the HDRS mean depression cluster score (in the tension headache group). At 90 days, clonidine had significantly reduced the HDRS mean total score (in the tension headache group) and HDRS mean anxiety cluster scores (in both groups).
在两个治疗组（普通偏头痛患者组和紧张性头痛患者组）中比较了α₂-激动剂可乐定和α₂-拮抗剂米安色林的疗效。40名患者参与了这项双盲安慰剂对照研究。安慰剂、0.150毫克可乐定和30毫克米安色林分别给药90天。通过静脉注射二盐酸组胺诱发头痛。普通偏头痛组的组胺阈值显著低于紧张性头痛组。在普通偏头痛组中，米安色林降低了头痛频率。在紧张性头痛组中，90天时米安色林显著降低了头痛强度和头痛频率。在普通偏头痛组中，90天时可乐定显著降低了头痛强度。90天时，米安色林显著降低了汉密尔顿抑郁量表（HDRS）的平均总分（在紧张性头痛组中）、HDRS平均焦虑因子得分（在两组中）以及HDRS平均抑郁因子得分（在紧张性头痛组中）。90天时，可乐定显著降低了HDRS平均总分（在紧张性头痛组中）和HDRS平均焦虑因子得分（在两组中）。
