Xu Qing, Ding Ning, Ma Dan, Lin HongJian, Lin Bingyong, Ma Xiaoming, Yang Jie, Guo Longhua
Jiaxing Key Laboratory of Molecular Recognition and Sensing; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, PR China.
School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China.
Anal Chem. 2024 Jul 17. doi: 10.1021/acs.analchem.3c05702.
A portable Hadamard-transform Raman spectrometer with excellent performance was fabricated consisting of a 785 nm laser, an optical filter, an optical system, a control system, and a signal processing system. As the core of the spectrometer, the optical system was composed of a slit, collimator, optical grating, reflector, digital micromirror devices (DMD), lens system, and InGaAs photodetector. Compared with a conventional dispersive Raman spectrometer, the proposed Raman spectrometer adopted the DMD and corresponding controlling device (DLPC350 control chip) to collect the Raman spectrum. Thus, in our design, the gratings are fixed, while the full Raman spectrum was collected by the deflection of the micromirror. This design can greatly improve the vibration resistance ability of the spectrometer since the gratings are not rotating during the spectrum collecting. More importantly, Hadamard-transform was used as signal processing technology, which has the ability of faster calculation, the merits of high energy input, single detector multichannel simultaneous detection (imaging) ability, and high signal-to-noise ratio (SNR). Hence, the Hadamard-transform portable Raman spectrometer has the potential to be applied in the field of point-of-care testing (POCT).
制造了一种性能优异的便携式哈达玛变换拉曼光谱仪，它由一台785 nm激光器、一个光学滤波器、一个光学系统、一个控制系统和一个信号处理系统组成。作为光谱仪的核心，光学系统由一个狭缝、准直器、光栅、反射镜、数字微镜器件（DMD）、透镜系统和铟镓砷光电探测器组成。与传统的色散拉曼光谱仪相比，所提出的拉曼光谱仪采用DMD和相应的控制装置（DLPC350控制芯片）来采集拉曼光谱。因此，在我们的设计中，光栅是固定的，而完整的拉曼光谱是通过微镜的偏转来采集的。这种设计可以大大提高光谱仪的抗振能力，因为在光谱采集过程中光栅不旋转。更重要的是，采用哈达玛变换作为信号处理技术，它具有计算速度快、能量输入高、单探测器多通道同时检测（成像）能力和高信噪比（SNR）的优点。因此，哈达玛变换便携式拉曼光谱仪有潜力应用于即时检测（POCT）领域。
