幕后的变化。
Changing behind the scenes.
机构信息
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
出版信息
J Exp Med. 2024 Aug 5;221(8). doi: 10.1084/jem.20240840. Epub 2024 Jul 17.
Abstract
Th17 cell plasticity is associated with pathogenicity in chronic inflammation. In a model of periodontitis, McClure et al. (https://doi.org/10.1084/jem.20232015) describe location-dependent divergence in Th17 plasticity, with surprisingly limited conversion in inflamed gingiva but emergence of protective exTh17-TfH cells in draining LN that enhance protective antibody.
摘要
Th17 细胞的可塑性与慢性炎症中的致病性有关。在牙周炎模型中，McClure 等人（https://doi.org/10.1084/jem.20232015）描述了 Th17 可塑性的位置依赖性差异，令人惊讶的是，在炎症性牙龈中几乎没有转化，但在引流 LN 中出现了保护性 exTh17-TfH 细胞，增强了保护性抗体。
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