Department of General Medicine, Zigong Fourth People's Hospital, Zigong, Sichuan, P.R. China.
Department of Cardiology, Zigong Fourth People's Hospital, Zigong, Sichuan, P.R. China.
Blood Press. 2024 Dec;33(1):2380002. doi: 10.1080/08037051.2024.2380002. Epub 2024 Jul 17.
To explore the association between serum folate concentration and the prevalence of elderly diastolic hypertension. This study aims to identify potential relationships that could inform further research into the mechanisms underlying hypertension management.
Data from six NHANES cycles (2007-2008, 2009-2010, 2011-2012, 2013-2014, 2015-2016, and 2017-2018) were analysed for individuals aged over 60. Weighted logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and restricted cubic spline (RCS) regression explored the serum folate concentration and elderly diastolic hypertension relationship.
This study included 9,419 participants (4,734 females and 4,685 males) with a mean age of 70.0 ± 7.0 years. Among them, 360 were diagnosed with diastolic hypertension. In the fully adjusted model, there was a negative correlation between serum folate concentration and the prevalence of diastolic hypertension (OR 0.65; 95% CI: 0.52-0.82). When serum folate concentration levels were divided into quartiles (in μg/dL), the ORs for diastolic hypertension corresponding to Q2 (1.29-1.98), Q3 (1.99-3.08), and Q4 (3.09-5.56) levels compared to Q1 (0.18-1.28) were 1.41 (95% CI: 0.60-3.33), 0.48(95% CI: 0.20-1.16), and 0.35 (95% CI: 0.16-0.74), respectively, with a P for trend <.05. Restricted cubic spline plots showed a negative correlation between serum folate concentration and the prevalence of diastolic hypertension (non-linearity: = .495). Subgroup analysis indicated that the negative correlation between serum folate concentration and the prevalence of diastolic hypertension was more significant in female participants (interaction = .009).
Higher serum folate concentration is associated with a lower prevalence of diastolic hypertension in the elderly.
探讨血清叶酸浓度与老年舒张期高血压患病率之间的关系。本研究旨在确定潜在的关系，为进一步研究高血压管理的机制提供信息。
对六个 NHANES 周期（2007-2008 年、2009-2010 年、2011-2012 年、2013-2014 年、2015-2016 年和 2017-2018 年）的数据进行了分析，研究对象为年龄超过 60 岁的人群。采用加权逻辑回归估计比值比（OR）和 95%置信区间（CI）。亚组和限制性三次样条（RCS）回归探索血清叶酸浓度与老年舒张期高血压的关系。
本研究共纳入 9419 名参与者（女性 4734 名，男性 4685 名），平均年龄为 70.0±7.0 岁。其中 360 名被诊断为舒张期高血压。在完全调整的模型中，血清叶酸浓度与舒张期高血压的患病率呈负相关（OR 0.65；95%CI：0.52-0.82）。当血清叶酸浓度水平分为四等分时（μg/dL），Q2（1.29-1.98）、Q3（1.99-3.08）和 Q4（3.09-5.56）水平对应的舒张期高血压 OR 值分别为 1.41（95%CI：0.60-3.33）、0.48（95%CI：0.20-1.16）和 0.35（95%CI：0.16-0.74），趋势 P 值<.05。受限三次样条图显示血清叶酸浓度与舒张期高血压的患病率呈负相关（非线性： = .495）。亚组分析表明，血清叶酸浓度与女性舒张期高血压患病率之间的负相关更为显著（交互作用： = .009）。
较高的血清叶酸浓度与老年人舒张期高血压的患病率较低有关。
