Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Zhejiang Chinese Medical University, Binjiang District, Hangzhou, China.
PLoS One. 2024 Jul 12;19(7):e0306636. doi: 10.1371/journal.pone.0306636. eCollection 2024.
Recent studies have established a correlation between folate levels and the incidence of cervical cancer. Given that Human Papillomavirus (HPV) infection is a primary etiological factor in the development of cervical cancer, the nature of the relationship between dietary folate intake and HPV infection remains an area of ongoing investigation.
To investigate the association between dietary folate intake and HPV infection, this study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2016. Multivariate logistic regression analysis was employed to examine the potential associations. Furthermore, the use of restricted cubic splines (RCS) facilitated the exploration of any non-linear correlations. Additionally, subgroup analyses were used to explore this correlation in different populations.
The study encompassed a total of 6747 women aged between 18 and 59 years. For every one mcg increase in folate intake, the incidence of HPV infection is reduced by 1% (OR = 0.99, p<0.05). Besides, folate intake was categorized into quartiles as follows: Q1 (<211 mcg/day), Q2 (211-311 mcg/day), Q3 (311-448 mcg/day), and Q4 (>448 mcg/day). The adjusted odds ratios (OR) for the different folate levels were as follows: Q2: 0.94 (95% CI: 0.76-1.16), Q3: 0.84 (95% CI: 0.67-1.04), and Q4: 0.63 (95% CI: 0.49-0.81). The RCS analysis confirmed a nonlinear relationship between dietary folate intake and HPV infection risk. Notably, a significant inverse association was observed when dietary folate intake exceeded 193.847 mcg/day.
In conclusion, the findings of this study indicate a negative association between dietary folate intake and the risk of HPV infection. This association demonstrates a nonlinear pattern, particularly evident at higher levels of folate consumption.
最近的研究已经确立了叶酸水平与宫颈癌发病率之间的相关性。鉴于人乳头瘤病毒（HPV）感染是宫颈癌发展的主要病因，膳食叶酸摄入与 HPV 感染之间的关系性质仍然是一个正在研究的领域。
为了研究膳食叶酸摄入与 HPV 感染之间的关联，本研究利用了 2005 年至 2016 年国家健康和营养调查（NHANES）的数据。采用多变量逻辑回归分析来检查潜在的关联。此外，使用限制性立方样条（RCS）来探索任何非线性相关性。此外，还进行了亚组分析，以探讨不同人群中的这种相关性。
该研究共纳入了 6747 名年龄在 18 至 59 岁之间的女性。叶酸摄入量每增加 1 mcg，HPV 感染的发生率就降低 1%（OR=0.99，p<0.05）。此外，叶酸摄入量分为四个四分位数：Q1（<211 mcg/天）、Q2（211-311 mcg/天）、Q3（311-448 mcg/天）和 Q4（>448 mcg/天）。不同叶酸水平的调整后比值比（OR）如下：Q2：0.94（95%CI：0.76-1.16），Q3：0.84（95%CI：0.67-1.04）和 Q4：0.63（95%CI：0.49-0.81）。RCS 分析证实了膳食叶酸摄入与 HPV 感染风险之间的非线性关系。值得注意的是，当膳食叶酸摄入量超过 193.847 mcg/天时，观察到显著的负相关关系。
总之，本研究的结果表明，膳食叶酸摄入与 HPV 感染风险之间存在负相关。这种关联呈现出非线性模式，尤其是在较高的叶酸摄入量水平下更为明显。
