新冠后综合征患儿循环活化血小板：病例对照初步观察
Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation.
作者信息
Buonsenso Danilo, Sorrentino Silvia, Ferretti Antonietta, Morello Rosa, Valentini Piero, Di Gennaro Leonardo, De Candia Erica
机构信息
From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Centro di Salute Globale, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Pediatr Infect Dis J. 2024 Jul 15;43(12):e430-3. doi: 10.1097/INF.0000000000004470.
We investigated if children with Long Covid (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long Covid had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin (P = 0.019).
我们调查了患有长期新冠的儿童（n = 14）与健康对照（n = 14）相比是否存在血小板活化情况。通过流式细胞术，使用针对P-选择素、CD63和PAC-1的单克隆抗体，在静息血小板以及用10 μM二磷酸腺苷和25 μM蛋白酶激活受体1激活肽刺激的血小板中，研究血小板活化和分泌标志物。患有长期新冠的患者循环血小板中，使用针对P-选择素的单克隆抗体的活化标志物流式细胞术表达显著增加（P = 0.019）。
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