Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China.
Department of Oncology, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730020, China.
Biomed Pharmacother. 2024 Aug;177:117068. doi: 10.1016/j.biopha.2024.117068. Epub 2024 Jul 16.
Precancerous lesions of gastric cancer (PLGC) represent a critical pathological stage in the transformation from normal gastric mucosa to gastric cancer (GC). The global incidence of PLGC has been rising over the past few decades, with a trend towards younger onset ages. Increasing evidence suggests that early prevention and treatment of PLGC can effectively reverse the malignant development of gastric mucosal epithelial cells. However, there is currently a lack of effective therapeutic drugs and methods. Recent years have witnessed substantial advancements in PLGC research, with the elucidation of novel regulatory mechanisms offering promising avenues for clinical intervention and drug development. This review aims to delineate potential targets for early prevention and diagnosis of GC while exploring innovative approaches to PLGC management. This article focuses on elucidating the regulatory mechanisms of the inflammatory microenvironment, bile acids (BA), glycolysis, autophagy, apoptosis, ferroptosis, and cellular senescence. We pay particular attention to potential therapeutic targets for PLGC, with the goal of providing insights and theoretical basis for clinical research on PLGC.
胃癌前病变（PLGC）代表了从正常胃黏膜向胃癌（GC）转化的一个关键病理阶段。在过去几十年中，PLGC 的全球发病率一直在上升，且发病年龄呈年轻化趋势。越来越多的证据表明，早期预防和治疗 PLGC 可以有效逆转胃黏膜上皮细胞的恶性发展。然而，目前缺乏有效的治疗药物和方法。近年来，PLGC 的研究取得了重大进展，新的调控机制的阐明为临床干预和药物开发提供了有前途的途径。本综述旨在阐述 GC 早期预防和诊断的潜在靶点，同时探索 PLGC 管理的创新方法。本文重点阐述了炎症微环境、胆汁酸（BA）、糖酵解、自噬、细胞凋亡、铁死亡和细胞衰老的调控机制。我们特别关注 PLGC 的潜在治疗靶点，旨在为 PLGC 的临床研究提供见解和理论基础。
