J Am Vet Med Assoc. 2024 Jul 17;262(11):1526-1532. doi: 10.2460/javma.24.01.0057. Print 2024 Nov 1.
We identified the associated factors and compared the survival times of feline hyperthyroidism (FHT) between thyroidectomy and methimazole alone.
The medical records of 41 cats diagnosed with new-onset hyperthyroidism were retrospectively reviewed. The cats were categorized into the thyroidectomy (n = 15) and methimazole (26) treatment groups. Survival analyses using the Kaplan-Meier method, log-rank test, and Cox proportional hazards models were conducted to compare the time to the selected outcomes.
Univariate analysis revealed that survival time was significantly longer with thyroidectomy than with methimazole (P < .001). Multivariate analyses revealed thyroidectomy as an independent prognostic factor for good outcomes (hazard ratio, 0.209; 95% CI, 0.073 to 0.601; P = .004). The recurrence rate was significantly lower in cats that underwent thyroidectomy than in those that received methimazole alone (P = .011).
Compared with methimazole alone, thyroidectomy was associated with a longer survival time in FHT and can be considered an irreversible treatment modality in settings where radioisotopes are not available.
我们确定了相关因素，并比较了甲状腺切除术和单独使用甲巯咪唑治疗猫甲状腺功能亢进（FHT）的生存时间。
回顾性分析了 41 只新诊断为甲状腺功能亢进的猫的病历。将猫分为甲状腺切除术（n=15）和甲巯咪唑（26）治疗组。使用 Kaplan-Meier 方法、对数秩检验和 Cox 比例风险模型进行生存分析，比较选择结果的时间。
单因素分析显示，甲状腺切除术的生存时间明显长于甲巯咪唑（P<.001）。多因素分析显示，甲状腺切除术是良好预后的独立预测因素（风险比，0.209；95%可信区间，0.073 至 0.601；P=0.004）。与单独使用甲巯咪唑相比，接受甲状腺切除术的猫复发率显著降低（P=0.011）。
与单独使用甲巯咪唑相比，甲状腺切除术与 FHT 的生存时间延长相关，在无法获得放射性同位素的情况下，可将其视为一种不可逆转的治疗方式。
