Center for Behavioral Health Research, University of Tennessee Knoxville, 600 Henley St, Suite 221, Knoxville, TN 37996, United States.
Center for Behavioral Health Research, University of Tennessee Knoxville, 600 Henley St, Suite 221, Knoxville, TN 37996, United States.
Contemp Clin Trials. 2024 Sep;144:107635. doi: 10.1016/j.cct.2024.107635. Epub 2024 Jul 15.
Approximately 16.5% of U.S. young adults have a cannabis use disorder (CUD) and are at risk for negative outcomes. Treatment can reduce cannabis use, but young adults are less likely to seek help than older adults. Peer Network Counseling-txt (PNC-txt) is a brief, text-delivered, Motivational Interviewing-informed substance use intervention focusing on peer relations and activity spaces as mechanisms for behavioral change. PNC-txt has shown evidence of reducing tobacco and cannabis use with adolescents and young adults, but it has not been tested in the context of legal cannabis use. The current randomized controlled trial sought to expand the evidence regarding the context of PNC-txt effects, comparing one state in which cannabis is legal (Colorado) and one state in which it is not (Tennessee). We hypothesized that participants randomized to PNC-txt would show significant reductions in cannabis use compared to controls, with larger reductions for females and those in Colorado, and that peer relations and activity space would mediate effects.
One thousand, seventy eight 18-25 year olds (CO: 551; TN: 527) who met screening criteria for CUD and biologically-verified cannabis use were randomly assigned to PNC-txt or waitlist control condition. Every other day for 4 weeks, participants assigned to PNC-txt received pre-programmed text conversations, tailored via data from the baseline assessment. Self-report and biological indicators of cannabis use were measured at 1-, 3-, and 6-months.
Data analysis is underway. Results will provide evidence regarding whether, and how, PNC-txt reduces cannabis use in young adults with CUD.
This trial was prospectively registered on September 28, 2020 with ClinicalTrials.gov (NCT04567394).
大约 16.5%的美国年轻人患有大麻使用障碍（CUD），并面临负面后果的风险。治疗可以减少大麻的使用，但年轻人寻求帮助的可能性低于老年人。同伴网络咨询-短信（PNC-txt）是一种简短的、通过短信传递的、以动机访谈为基础的物质使用干预措施，侧重于同伴关系和活动空间作为行为改变的机制。PNC-txt 已经证明可以减少青少年和年轻人的烟草和大麻使用，但尚未在合法大麻使用的背景下进行测试。目前的随机对照试验旨在扩大关于 PNC-txt 效果背景的证据，比较一个大麻合法的州（科罗拉多州）和一个大麻不合法的州（田纳西州）。我们假设，与对照组相比，随机分配到 PNC-txt 的参与者的大麻使用量会显著减少，女性和科罗拉多州的参与者减少幅度更大，并且同伴关系和活动空间将介导这些效果。
符合 CUD 筛查标准和生物验证大麻使用的 1078 名 18-25 岁的年轻人（CO：551；TN：527）被随机分配到 PNC-txt 或候补名单对照组。在 4 周内，每隔一天，分配到 PNC-txt 的参与者会收到预先编程的短信对话，这些对话是根据基线评估的数据量身定制的。大麻使用的自我报告和生物指标在 1、3 和 6 个月时进行测量。
数据分析正在进行中。结果将提供有关 PNC-txt 是否以及如何在患有 CUD 的年轻成年人中减少大麻使用的证据。
该试验于 2020 年 9 月 28 日前瞻性地在 ClinicalTrials.gov 上注册（NCT04567394）。
