Xu Jian, Peng Tingting, Kong Lingti, Wei Nana
Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Department of Vertebral Column Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
BMC Cardiovasc Disord. 2025 Mar 15;25(1):188. doi: 10.1186/s12872-025-04620-z.
Ischemic heart disease (IHD) is a major contributor to global mortality and disability, imposing a significant health and economic burden on patients and society. Despite existing treatment options including medications and surgeries, their effectiveness remains limited, with issues such as suboptimal treatment outcomes and high recurrence rates. This study aims to investigate the relationship between low dietary intake of ω-3 fatty acids and the burden of IHD, hoping to provide new insights into the prevention and treatment of IHD.
Using the Global Burden of Disease (GBD) 2021 dataset, we examined the impact of low ω-3 dietary intake on the burden of ischemic heart disease (IHD) between 1990 and 2021globally, regionally, temporally. The Joinpoint regression model was applied to analyze the trend of IHD burden attributed to low ω-3 dietary intake over time.
In 2021, the global IHD-related Disability-Adjusted Life Years (DALYs) and deaths caused by a low ω-3 diet was 15,511,020(95% UI: 3,098,820 to 25,946,110) and 627,340 (95% UI: 119,540 to 1,082,740), accounting for 8.23% (95% UI: 1.64-13.52%) of all IHD-related DALYs and 6.97% (95% UI: 1.33-11.76%) of all IHD deaths, respectively. From 1990 to 2021, there was a significant upward trend in DALYs and deaths, but age-standardized DALYs and death rates showed a declining trend. Regional analysis indicated that the burden of IHD was highest in South Asia and lowest in High-Income Asia Pacific regions. At the national level, India, China, the United States, and Pakistan had a higher burden of IHD. Furthermore, as the Socio-Demographic Index (SDI) increased, the burden of IHD caused by a low ω-3 diet gradually decreased.
This study untangles a significant association between a low ω-3 diet and the burden of IHD, emphasizing the importance of promoting healthy eating habits globally. Future research should further explore the impact of dietary changes on the burden of IHD and develop targeted public health policies to reduce the burden of IHD.
缺血性心脏病（IHD）是全球死亡和残疾的主要原因，给患者和社会带来了巨大的健康和经济负担。尽管现有包括药物和手术在内的治疗选择，但其有效性仍然有限，存在治疗效果欠佳和复发率高等问题。本研究旨在探讨低ω-3脂肪酸饮食摄入与缺血性心脏病负担之间的关系，希望为缺血性心脏病的预防和治疗提供新的见解。
使用全球疾病负担（GBD）2021数据集，我们在全球、区域和时间层面上研究了低ω-3饮食摄入对1990年至2021年间缺血性心脏病（IHD）负担的影响。应用Joinpoint回归模型分析低ω-3饮食摄入所致缺血性心脏病负担随时间的变化趋势。
2021年，全球因低ω-3饮食导致的与缺血性心脏病相关的伤残调整生命年（DALYs）和死亡数分别为15,511,020（95%UI：3,098,820至25,946,110）和627,340（95%UI：119,540至1,082,740），分别占所有缺血性心脏病相关DALYs的8.23%（95%UI：1.64 - 13.52%）和所有缺血性心脏病死亡数的6.97%（95%UI：1.33 - 11.76%）。1990年至2021年，DALYs和死亡数呈显著上升趋势，但年龄标准化DALYs和死亡率呈下降趋势。区域分析表明，南亚缺血性心脏病负担最高，高收入亚太地区最低。在国家层面，印度、中国、美国和巴基斯坦的缺血性心脏病负担较高。此外，随着社会人口指数（SDI）的增加，低ω-3饮食导致的缺血性心脏病负担逐渐降低。
本研究揭示了低ω-3饮食与缺血性心脏病负担之间的显著关联，强调了在全球推广健康饮食习惯的重要性。未来的研究应进一步探索饮食变化对缺血性心脏病负担的影响，并制定有针对性的公共卫生政策以减轻缺血性心脏病负担。
