Department of Public Health, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Sci Total Environ. 2024 Oct 20;948:174748. doi: 10.1016/j.scitotenv.2024.174748. Epub 2024 Jul 15.
Human health is commonly threatened by organophosphorus pesticides (OPPs) due to their widespread use and biological characteristics. However, the combined effect of mixtures of OPPs metabolites on the risk of hypertension and potential mechanism remain limited.
To comprehensively investigate the effects between OPPs exposure on hypertension risk and explore and underlying mechanism among US general population.
This cross-sectional study collected US adults who had available data on urine OPPs metabolites (dialkyl phosphate compounds, DAPs) from the National Health and Nutrition Examination Survey (NHANES) to assess the relationships of DAPs with hypertension risk. Survey-weighted logistic regression, restricted cubic spline (RCS), and mixed exposure analysis models [weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR)] were used to analyze individual, dose-response and combined associations between urinary DAPs metabolites and hypertension risk, respectively. Mediation analysis determined the potential intermediary role of serum albumin and liver function in the above associations.
Compared with the reference group, participants with the highest tertile levels of DEP, DMTP, DETP, and DMDTP experienced increased risk of hypertension by 1.21-fold (95%CI: 1.02-1.36), 1.20-fold (95%CI: 1.02-1.42), 1.19-fold (95%CI: 1.01-1.40), and 1.17-fold (95%CI: 1.03-1.43), respectively. RCS curve also showed positive exposure-response associations of individual DAPs with hypertension risk. WQS and BKMR analysis further confirmed DAP mixtures were significantly associated with increased risk of hypertension, with DEP identified as a major contributor to the combined effect. Mediation analysis indicated that serum albumin and AST/ALT ratios played crucial mediating roles in the relationships between individual and mixed urinary DAPs and the prevalence of hypertension.
Our findings provided more comprehensive and novel perspectives into the individual and combined effects of urinary OPPs matabolites on the increased risk of hypertension and the possible driving mechanism, which would be of great significance for environmental control and early prevention of hypertension.
由于有机磷农药（OPPs）的广泛使用和生物学特性，人类健康经常受到威胁。然而，OPPs 代谢物混合物对高血压风险的综合影响及其潜在机制仍有限。
全面研究 OPPs 暴露对高血压风险的影响，并探索美国普通人群中潜在的机制。
本横断面研究从国家健康和营养调查（NHANES）中收集了美国成年人尿液 OPPs 代谢物（二烷基磷酸化合物，DAPs）的数据，以评估 DAPs 与高血压风险之间的关系。使用调查加权逻辑回归、限制立方样条（RCS）和混合暴露分析模型[加权分位数和回归（WQS）和贝叶斯核机器回归（BKMR）]分别分析个体、剂量-反应和联合与高血压风险之间的关系。中介分析确定了血清白蛋白和肝功能在上述关联中的潜在中介作用。
与参考组相比，DET、DMTP、DETP 和 DMDTP 最高三分位组的参与者患高血压的风险增加了 1.21 倍（95%CI：1.02-1.36）、1.20 倍（95%CI：1.02-1.42）、1.19 倍（95%CI：1.01-1.40）和 1.17 倍（95%CI：1.03-1.43）。RCS 曲线还显示了个体 DAPs 与高血压风险的正暴露反应关系。WQS 和 BKMR 分析进一步证实了 DAP 混合物与高血压风险的显著相关性，其中 DET 被确定为联合效应的主要贡献者。中介分析表明，血清白蛋白和 AST/ALT 比值在个体和混合尿液 DAPs 与高血压患病率之间的关系中发挥了关键的中介作用。
我们的研究结果提供了更全面和新颖的视角，了解尿液 OPPs 代谢物对高血压风险增加的个体和综合影响及其可能的驱动机制，这对于环境控制和高血压的早期预防具有重要意义。
