Xu Rongjiang, Yu Xiangmin, Zhang Ruonan, Xu Xiaonuo, Fan Xiaoping, Dong Liang, Zhou Jiying
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Phase I Clinical Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Nutr. 2025 May 6;12:1547371. doi: 10.3389/fnut.2025.1547371. eCollection 2025.
The pathogenesis of migraine is not fully understood until now. This study was designed to explore whether the intake of live dietary microbes could be used as an auxiliary means for the treatment of severe headache and migraine.
Data used in this study were came from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Participants were divided into three groups according to the dietary live microbe classification system, namely low, medium and high dietary live microbe groups. Weighted logistic regression models were used for statistical analysis.
A total of 13,443 participants were included in the present study. Compared with the low dietary live microorganism group, the migraine OR (95% CI) of medium-high dietary live microorganism group is 0.71 (0.63-0.81) and 0.73 (0.62-0.86), respectively, in the unadjusted model. After fully adjusting for confounding factors, patients in medium-high dietary live microbe group had a lower prevalence of migraine in contrast to those in low dietary live microbe group (Medium OR: 0.79, 95% CI: 0.68-0.93, = 0.005; High OR: 0.82, 95% CI: 0.67-0.99, = 0.047).
Our study shows that a moderate-high intake of live dietary microbes is inversely associated with the prevalence of severe headache or migraine.
偏头痛的发病机制至今尚未完全明确。本研究旨在探讨摄入活性膳食微生物是否可作为治疗重度头痛和偏头痛的辅助手段。
本研究使用的数据来自1999年至2004年的美国国家健康与营养检查调查（NHANES）。参与者根据膳食活性微生物分类系统分为三组，即低、中、高膳食活性微生物组。采用加权逻辑回归模型进行统计分析。
本研究共纳入13443名参与者。在未调整模型中，与低膳食活性微生物组相比，中高膳食活性微生物组的偏头痛优势比（95%可信区间）分别为0.71（0.63 - 0.81）和0.73（0.62 - 0.86）。在对混杂因素进行充分调整后，与低膳食活性微生物组相比，中高膳食活性微生物组的偏头痛患病率较低（中组优势比：0.79，95%可信区间：0.68 - 0.93，P = 0.005；高组优势比：0.82，95%可信区间：0.67 - 0.99，P = 0.047）。
我们的研究表明，适度高摄入活性膳食微生物与重度头痛或偏头痛的患病率呈负相关。
