School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055 China.
Education Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen 518055, China.
Drug Discov Today. 2024 Sep;29(9):104101. doi: 10.1016/j.drudis.2024.104101. Epub 2024 Jul 15.
This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal-organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.
这篇综述重点介绍了基于锰（Mn）配合物的磁共振成像（MRI）造影剂在不同疾病成像方面的最新进展。文中强调了 Mn 的独特氧化还原性质在提供创新 MRI 造影剂方面的作用，包括小分子、纳米粒子（NPs）、金属有机骨架（MOFs）和聚合物杂化材料。本文还讨论了这些造影剂的合理设计，包括尺寸依赖性、形态调谐、表面性能增强等方面，同时也讨论了当前存在的挑战和潜在的解决方案。本工作将激发和激励科学家们重视 MRI 引导的应用，并在未来几年带来临床成功。
