The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Department of General Surgery, Dongguan People's Hospital, Wanjiang District, Dongguan 523000, China.
Colloids Surf B Biointerfaces. 2022 May;213:112432. doi: 10.1016/j.colsurfb.2022.112432. Epub 2022 Mar 2.
Manganese-based Metal-organic Frameworks (Mn-MOFs) represents a unique sub-class of MOFs with low toxicity, oxidative ability, and biocompatibility, which plays vital role in the application of this class of MOFs in medical field. Mn-MOFs show great potential in biomedical applications, and has been extensively studied as compared to other MOFs in transition metal series. They are important in medical applications because Mn(II) possess large electron spin number and longer electron relaxation time. They display fast water exchange rate and could be employed as a potential MRI contrast agent because of their strong targeting ability. Manganese complexes with different ligands also display prospective applications in area such as carrier for drug targeting in anti-tumor and antimicrobial therapy. In the review presented herewith, the application of Mn-based complexes and Mn-MOFs have been emphasized in the area such as imaging viz. MRI, multimodal imaging, antitumor activities such as chemodynamic therapy, photodynamic therapy, sonodynamic therapy and antimicrobial applications. Also, how rational designing and syntheses of targeted Mn-based complexes and Mn-MOFs can engender desired applications.
基于锰的金属有机骨架（Mn-MOFs）代表了一类具有低毒性、氧化性和生物相容性的独特 MOFs 亚类，在该类 MOFs 在医学领域的应用中发挥着重要作用。Mn-MOFs 在生物医学应用中具有巨大的潜力，与过渡金属系列中的其他 MOFs 相比，已经得到了广泛的研究。它们在医学应用中很重要，因为 Mn(II) 具有较大的电子自旋数和较长的电子弛豫时间。它们具有较快的水交换率，并且由于其强大的靶向能力，可用作潜在的 MRI 造影剂。具有不同配体的锰配合物也在载药靶向抗肿瘤和抗菌治疗等领域具有广阔的应用前景。在本文综述中，强调了基于锰的配合物和 Mn-MOFs 在成像（如 MRI、多模态成像）、抗肿瘤活性（如化学动力学治疗、光动力治疗、声动力治疗）和抗菌应用等方面的应用。此外，如何通过合理设计和合成靶向 Mn 配合物和 Mn-MOFs 来产生所需的应用。
