Suppr超能文献

预防性肌肉皮瓣在有假体旁路的高愈合不良风险患者中增加了深部伤口并发症。

Prophylactic muscle flaps in high-risk-for-poor-healing patients with prosthetic bypasses increases deep wound complications.

机构信息

The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Department of Surgery, The George Washington University Hospital, Washington, District of Columbia, USA.

出版信息

World J Surg. 2024 Oct;48(10):2543-2550. doi: 10.1002/wjs.12296. Epub 2024 Jul 17.

Abstract

BACKGROUND

Incisional complications of groin after inflow or infrainguinal bypasses with prosthetic conduits can result in major morbidities that require reoperation, infected graft removal, and limb loss. Muscle flaps are typically performed to treat groin wound complications, but they are also done prophylactically at the time of index procedures in certain high-risk-for-poor-healing patients to mitigate anticipated groin wound complications. We used a nationwide multi-institutional database to investigate outcomes of prophylactic muscle flaps in high-risk patients who underwent prosthetic bypasses involving femoral anastomosis.

METHODS

We utilized ACS-NSQIP database 2005-2021 to identify all elective inflow and infrainguinal bypasses that involve femoral anastomoses. Only high-risk patients for poor incisional healing who underwent prosthetic conduit bypasses were selected. A 1:3 propensity-matching was performed to obtain two comparable studied groups between those with (FLAP) and without prophylactic muscle flaps (NOFLAP) based on demographics and comorbidities. 30-day postoperative outcomes were compared.

RESULTS

Among 35,011 NOFLAP, 990 of them were propensity-matched to 330 FLAP. There was no significant difference in 30-day mortality, MACE, pulmonary, or renal complications. FLAP was associated with higher bleeding requiring transfusion, longer operative time, and longer hospital stay. FLAP also had higher overall wound complications (15.2% vs. 10.6%; p = 0.03), especially deep incisional infection (4.9% vs. 2.4%; p = 0.04).

CONCLUSION

Prophylactic muscle flap for prosthetic bypasses involving femoral anastomosis in high-risk-for-poor-healing patients does not appear to mitigate 30-day wound complications. Caution should be exercised with this practice and more long-term data should be obtained to determine whether prophylactic flaps decrease the incidence of graft infection.

摘要

背景

带假体血管移植物的流入道或流入道以下旁路手术后腹股沟切口并发症可导致严重的并发症,需要再次手术、感染移植物移除和肢体丧失。肌肉皮瓣通常用于治疗腹股沟伤口并发症,但在某些愈合不良高风险患者的指数手术中也预防性地进行,以减轻预期的腹股沟伤口并发症。我们使用全国多机构数据库调查了在接受涉及股吻合术的假体旁路的高风险患者中预防性肌肉皮瓣的结果。

方法

我们利用 ACS-NSQIP 数据库 2005-2021 年,确定所有涉及股吻合术的选择性流入道和流入道以下旁路。仅选择假体血管移植物旁路手术中愈合不良高风险的高危患者。根据人口统计学和合并症,对有(FLAP)和无预防性肌肉皮瓣(NOFLAP)的高危患者进行 1:3 倾向匹配,获得两个可比的研究组。比较 30 天术后结果。

结果

在 35011 例 NOFLAP 中,有 990 例与 330 例 FLAP 进行了倾向匹配。30 天死亡率、MACE、肺部或肾脏并发症无显著差异。FLAP 与需要输血的出血量更大、手术时间更长和住院时间更长相关。FLAP 也有更高的总体伤口并发症(15.2% vs. 10.6%;p=0.03),尤其是深部切口感染(4.9% vs. 2.4%;p=0.04)。

结论

对于愈合不良高风险的假体旁路手术,预防性肌肉皮瓣似乎不能减轻 30 天伤口并发症。在实践中应谨慎对待这种做法,应获得更多的长期数据,以确定预防性皮瓣是否会降低移植物感染的发生率。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验