Tomsho Kathryn S, Quinn Marlee R, Preston Emma V, Adamkiewicz Gary, James-Todd Tamarra
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J Expo Sci Environ Epidemiol. 2024 Jul 17. doi: 10.1038/s41370-024-00706-6.
Perinatal exposure to phthalates is associated with adverse health impacts for parents and children. The field of environmental health literacy seeks to measure how environmental health information is conceptualized and used to inform behaviors. We assessed whether scores on the validated Phthalate Environmental Reproductive Health Literacy (PERHL) scale were associated with biomarkers of phthalate exposure.
42 members of the Environmental Reproductive and Glucose Outcomes (ERGO) cohort completed the PERHL scale and provided spot urine samples. Phthalate summary measures for model outcomes were created by calculating molar sums of specific gravity-corrected metabolite concentrations representing exposure to parent phthalate, Di(2-ethylhexyl)phthalate (DEHP), personal care product (PCP)-associated phthalates, and parent butyl-phthalates. Linear regression models were used to estimate the associations of the PERHL scale scores with phthalate summary measures, controlling for educational attainment (college degree or higher vs. no college degree), age (years), and race and ethnicity (non-Hispanic White vs. non-White).
Higher scores on the PERHL Scale and subscales were generally associated with lower ΣDEHP, Σbutyl, and ΣPCP metabolite concentrations. A one-point increase in the 'Protective Behavior/Risk Control' subscale score was significantly associated with a -30.3% (95% CI: -50.1, -2.6) decrease in ΣDEHP, and a -30.6% (95% CI: -51.5, -0.63) decrease in Σbutyl metabolite concentrations.
围产期接触邻苯二甲酸盐与父母及儿童的不良健康影响相关。环境卫生素养领域旨在衡量环境卫生信息如何被概念化并用于指导行为。我们评估了经过验证的邻苯二甲酸盐环境生殖健康素养（PERHL）量表得分是否与邻苯二甲酸盐暴露的生物标志物相关。
环境生殖与血糖结局（ERGO）队列的42名成员完成了PERHL量表并提供了即时尿样。通过计算代表母体邻苯二甲酸盐、邻苯二甲酸二（2-乙基己基）酯（DEHP）、个人护理产品（PCP）相关邻苯二甲酸盐和母体丁基邻苯二甲酸盐暴露的比重校正代谢物浓度的摩尔总和，创建了模型结局的邻苯二甲酸盐汇总指标。使用线性回归模型估计PERHL量表得分与邻苯二甲酸盐汇总指标之间的关联，并控制教育程度（大学学位或更高与无大学学位）、年龄（岁）以及种族和民族（非西班牙裔白人与非白人）。
PERHL量表及其子量表得分较高通常与较低的ΣDEHP、Σ丁基和ΣPCP代谢物浓度相关。“保护行为/风险控制”子量表得分每增加1分，与ΣDEHP降低30.3%（95%CI：-50.1，-2.6）以及Σ丁基代谢物浓度降低30.6%（95%CI：-51.5，-0.63）显著相关。
