Shvachkin Iu P, Nikitina A M, Funtova S M, Krasnoshchekova S P, Fedotov V P
Biokhimiia. 1985 Sep;50(9):1560-1.
Enzymatic-chemical preparation of glycine-B30-insulin, a new structural analog of human insulin has been performed. The new analog differs from the natural hormone by a substituted ThrB30 residue in the glycine residue. The biological activity of the glycine-B30-insulin as measured by the mouse convulsion assay is 100%.
已完成甘氨酸 - B30胰岛素(一种人胰岛素的新结构类似物)的酶促 - 化学制备。这种新类似物与天然激素的不同之处在于,其B30位的苏氨酸残基被甘氨酸残基取代。通过小鼠惊厥试验测定,甘氨酸 - B30胰岛素的生物活性为100%。