School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Int J Food Sci Nutr. 2024 Sep;75(6):582-596. doi: 10.1080/09637486.2024.2379817. Epub 2024 Jul 17.
DNA methylation GrimAge acceleration (DMGA) and intrinsic epigenetic age acceleration (IEAA) are important physiological markers for assessing the ageing process. Evidence from cross-sectional studies suggests that some dietary intake is associated with DMGA and IEAA. However, the causal relationship between them has yet to be elucidated. This Mendelian randomisation study uses genetic variants associated with different dietary intakes as instrumental variables to explore the causal benefits of multiple dietary intakes on DMGA and IEAA. Cheese intake, dark chocolate intake, average weekly red wine intake, dried fruit intake, fresh fruit intake, porridge intake, cereal intake, and liver intake had a negative causal association with DMGA, and poultry intake and doughnut intake had a positive causal association with DMGA ( < 0.05). Muesli and bran cereal intake had a negative causal association with IEAA, and pineapple intake had a positive causal association with IEAA ( < 0.05). Dietary intake positively causally associated with IEAA or DMGA may have accelerated biological ageing; conversely, dietary intake negatively causally associated with IEAA or DMGA may have contributed to delaying biological ageing. Based on genetic evidence, this study demonstrated some significant causal benefits of dietary intake on DMGA and IEAA, suggesting the possibility of intervening in DNA methylation acceleration and epigenetic age acceleration by adjusting these food intakes, thereby promoting health and delaying ageing. However, the findings of this study are exploratory and preliminary and need to be supported and validated by evidence from further clinical studies and mechanistic studies.
DNA 甲基化 GrimAge 加速（DMGA）和内在表观遗传年龄加速（IEAA）是评估衰老过程的重要生理标志物。来自横断面研究的证据表明，某些饮食摄入与 DMGA 和 IEAA 有关。然而，它们之间的因果关系尚未阐明。本孟德尔随机化研究使用与不同饮食摄入相关的遗传变异作为工具变量，探讨多种饮食摄入对 DMGA 和 IEAA 的因果益处。奶酪摄入、黑巧克力摄入、每周平均红酒摄入、干果摄入、新鲜水果摄入、燕麦粥摄入、谷物摄入和肝脏摄入与 DMGA 呈负因果关系，而家禽摄入和甜甜圈摄入与 DMGA 呈正因果关系（<0.05）。早餐麦片和麸皮谷物摄入与 IEAA 呈负因果关系，菠萝摄入与 IEAA 呈正因果关系（<0.05）。与 IEAA 或 DMGA 呈正因果关系的饮食摄入可能加速了生物衰老；相反，与 IEAA 或 DMGA 呈负因果关系的饮食摄入可能有助于延缓生物衰老。基于遗传证据，本研究表明饮食摄入对 DMGA 和 IEAA 有一些显著的因果益处，这表明通过调整这些食物摄入来干预 DNA 甲基化加速和表观遗传年龄加速的可能性，从而促进健康和延缓衰老。然而，本研究的发现是探索性和初步的，需要进一步的临床研究和机制研究证据的支持和验证。
