Wajeepeptin，一种来源于海洋蓝藻的细胞毒性和抗锥虫环二肽。
Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine sp. Cyanobacterium.
机构信息
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Nat Prod. 2024 Jul 26;87(7):1838-1843. doi: 10.1021/acs.jnatprod.4c00499. Epub 2024 Jul 17.
Here, we report wajeepeptin (), a new cyclic depsipeptide isolated from a marine sp. cyanobacterium. The structure was elucidated by a combination of spectroscopic analyses, X-ray diffraction analysis, and degradation reactions. Wajeepeptin () showed moderate cytotoxicity (IC = 3.7 μM against HeLa cells) and potent antitrypanosomal activity (IC = 0.73 ± 0.14 μM against ).
在这里，我们报告了一种从海洋 蓝藻中分离得到的新型环二肽wajeepeptin()。通过光谱分析、X 射线衍射分析和降解反应的组合，确定了其结构。Wajeepeptin()表现出中等的细胞毒性（对 HeLa 细胞的 IC = 3.7 μM）和强大的抗锥虫活性（对 的 IC = 0.73 ± 0.14 μM）。
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