欧哈酰胺，一种源自海洋蓝藻细菌的抗寄生虫线性脂肽。
Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine sp. Cyanobacterium.
作者信息
Niiyama Mizuho, Kurisawa Naoaki, Umeda Kairi, Jeelani Ghulam, Agusta Adnan Luthfi, Nozaki Tomoyoshi, Suenaga Kiyotake
机构信息
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Nat Prod. 2025 Jun 27;88(6):1360-1368. doi: 10.1021/acs.jnatprod.5c00281. Epub 2025 May 16.
Ouhanamide (), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide () showed selective antiparasitic activity (IC = 1.2 ± 0.1 μM against and IC = 4.2 ± 0.9 μM against ) without cytotoxicity at 10 μM against HeLa cells.
欧哈酰胺（）是一种新的线性脂肽，由带有β-分支甲基的长链脂肪酸组成，从一种海洋蓝藻中分离得到。通过各种光谱分析、降解反应和衍生化反应相结合的方法阐明了其整体结构。欧哈酰胺（）表现出选择性抗寄生虫活性（对的IC = 1.2 ± 0.1 μM，对的IC = 4.2 ± 0.9 μM），在10 μM浓度下对HeLa细胞无细胞毒性。
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