Yadav Bindu Kumari, Patel Riya, Prajapati Bhupendra, Patel Gayatri
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT - Campus, Changa - 388421, Anand, Gujarat, India.
S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India.
Curr Pharm Biotechnol. 2024 Jul 15. doi: 10.2174/0113892010312939240704141630.
Skin cancer is one of the most common and complex types of the disease, resulting in a high mortality rate worldwide. Skin cancer can be treated with chemotherapy, surgery, radiotherapy, etc. In most cases, a patient's condition and the type of skin cancer determine the recommended treatment options. As a result of poor penetration of the drug into stratum corneum or lesions, low efficacy, and higher concentrations of active pharmaceutical ingredients required to achieve a therapeutic effect, the efficacy of skin cancer therapy has been limited. The high dose requirement, as well as poor bioavailability at the site of action, causes skin inflammation, which greatly hinders drug absorption. This review mainly focuses on research on nanocarriers for sitespecific and controlled delivery of therapeutics for skin cancer treatment. The information related to various nanocarriers systems for skin cancer will be illustrated. This also focused on patents, clinical trials, and research carried out in the field of liposomes, niosomes, ethosomes, nanoparticles, microemulsion, nanoemulsions, gels, nanogels, hydrogels, dendrimers, and nanofibers for treating skin cancer. Nanotechnology-based therapy has shown great promise in controlling skin cancer and can be used to deliver drugs more effectively.
皮肤癌是最常见且复杂的疾病类型之一，在全球范围内导致较高的死亡率。皮肤癌可以通过化疗、手术、放疗等方式进行治疗。在大多数情况下，患者的病情和皮肤癌的类型决定了推荐的治疗方案。由于药物对角质层或病变部位的渗透性差、疗效低，以及达到治疗效果所需的活性药物成分浓度较高，皮肤癌治疗的疗效一直受到限制。高剂量要求以及作用部位的生物利用度差会导致皮肤炎症，这极大地阻碍了药物吸收。本综述主要关注用于皮肤癌治疗的治疗剂的位点特异性和控释纳米载体的研究。将阐述与用于皮肤癌的各种纳米载体系统相关的信息。这也聚焦于在脂质体、非离子表面活性剂泡囊、醇质体、纳米颗粒、微乳、纳米乳、凝胶、纳米凝胶、水凝胶、树枝状大分子和纳米纤维等领域开展的用于治疗皮肤癌的专利、临床试验及研究。基于纳米技术的疗法在控制皮肤癌方面已显示出巨大潜力，并且可用于更有效地递送药物。
