Xie Haimei, Yu Jia, Ou Zhiwen, Lei Xiaoyong, Yang Xiaoyan
School of Pharmaceutical Science, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China.
Chuanshan College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China.
Curr Pharm Biotechnol. 2024 Jul 15. doi: 10.2174/0113892010311953240628084818.
Cancer is one of the main reasons for death, and it threatens human life and health. Both the environment and genes can lead to cancers. It dates back more than a million years; more importantly, tumor cells can not be detected until they grow to a large number. Currently, cancers are treated with surgical excision or non-surgical procedures. By studying the interaction between ncRNAs and PKM2, we aim to provide new targets for diagnosis, treatment, and prognosis for cancers. Read relevant articles and made a summary and classification. Non-coding RNAs (ncRNAs) are RNAs that do not code for proteins. They perform a function in transcription and translation and can be used as targets for cancer therapy. Pyruvate kinase M2 (PKM2) is a form of PKM, and it catalyzes the glycolysis of the final cellular processes to promote tumorigenesis. Not only that, but it also plays non-metabolic functions, including the expression of the gene, cell proliferation, cell migration, and tumor angiogenesis in cancer cells. The existing studies have found that microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) can promote or inhibit the aerobic glycolysis of cancer cells by affecting PKM2, which increases or decrease the risk of cancers and affect the progression of cancers. This review focuses on the mechanism of ncRNAs regulating PKM2 in cancers and summarizes the roles of some ncRNAs.
癌症是主要的死亡原因之一，威胁着人类的生命和健康。环境和基因都可能导致癌症。这可以追溯到一百多万年前；更重要的是，直到肿瘤细胞大量生长才能被检测到。目前，癌症通过手术切除或非手术程序进行治疗。通过研究非编码RNA（ncRNAs）与丙酮酸激酶M2（PKM2）之间的相互作用，我们旨在为癌症的诊断、治疗和预后提供新的靶点。阅读了相关文章并进行了总结和分类。非编码RNA（ncRNAs）是不编码蛋白质的RNA。它们在转录和翻译中发挥作用，可作为癌症治疗的靶点。丙酮酸激酶M2（PKM2）是PKM的一种形式，它催化细胞最终过程的糖酵解以促进肿瘤发生。不仅如此，它还发挥非代谢功能，包括癌细胞中基因的表达、细胞增殖、细胞迁移和肿瘤血管生成。现有研究发现，微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）可通过影响PKM2促进或抑制癌细胞的有氧糖酵解，这增加或降低了患癌风险并影响癌症进展。本综述重点关注ncRNAs在癌症中调节PKM2的机制，并总结了一些ncRNAs的作用。
