Sun Yiyang, He Ping, Li Li, Ding Xue
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.
General Medicine Department, Dalian Friendship Hospital, Dalian, China.
Front Oncol. 2023 Jan 16;12:969032. doi: 10.3389/fonc.2022.969032. eCollection 2022.
Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC. It seriously threatens the life and health of patients because of its early metastasis, late clinical symptoms, limited early screening methods, and poor treatment outcomes. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in cell proliferation, metastasis, and chemoresistance. Several previous studies have proven that ncRNAs are vital regulators of tumorigenesis. Ubiquitination plays the most crucial role in protein post-translational modification (PTM). Deubiquitination and ubiquitination form a homeostasis. In summary, ubiquitination and deubiquitination play essential roles in mediating the degradation or overexpression of a range of crucial proteins in various cancers. A growing number of researchers have found that interactions between ncRNAs and ubiquitination (or deubiquitination) play a crucial role in NSCLC. This review presents several typical examples of the important effects of ncRNAs and ubiquitination (or deubiquitination) in NSCLC, aiming to provide more creative ideas for exploring the diagnosis and treatment of NSCLC.
肺癌（LC）仍然是全球癌症相关死亡的主要原因，其发病率和死亡率极高。非小细胞肺癌（NSCLC）是LC最主要的类型。由于其早期转移、临床症状出现较晚、早期筛查方法有限以及治疗效果不佳，它严重威胁着患者的生命和健康。非编码RNA（ncRNAs），包括微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），参与细胞增殖、转移和化疗耐药。先前的几项研究已经证明，ncRNAs是肿瘤发生的重要调节因子。泛素化在蛋白质翻译后修饰（PTM）中起着至关重要的作用。去泛素化和泛素化形成一种稳态。总之，泛素化和去泛素化在介导各种癌症中一系列关键蛋白的降解或过表达方面发挥着重要作用。越来越多的研究人员发现，ncRNAs与泛素化（或去泛素化）之间的相互作用在NSCLC中起着关键作用。本综述展示了ncRNAs和泛素化（或去泛素化）在NSCLC中的重要作用的几个典型例子，旨在为探索NSCLC的诊断和治疗提供更多创新思路。
