Wang Juan, Huang Yongqi, Wu Liuliu, Sun Yaoyao, Zhang Xuan, Cao Fenglin
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, China.
J Sleep Res. 2025 Feb;34(1):e14272. doi: 10.1111/jsr.14272. Epub 2024 Jul 18.
Insomnia symptoms are highly prevalent during pregnancy; therefore, identifying modifiable risk markers is important for risk prediction and early intervention. This study aimed to examine the role of sleep-specific rumination and sleep-specific worry in prenatal insomnia symptoms. A total of 859 married pregnant women without history of psychiatric illnesses (mean [standard deviation] age, 30.15 [3.86] years; 593 [69.0%] with a bachelor's degree or above) were enrolled from the obstetrical outpatient departments of two tertiary comprehensive hospitals in Shandong, China, who completed assessments of sleep-specific rumination, sleep-specific worry, and insomnia symptoms at baseline (mid-pregnancy) and follow-up (late-pregnancy). Measures included Daytime Insomnia Symptom Response Scale, Anxiety and Preoccupation about Sleep Questionnaire, and Insomnia Severity Index. Our results showed that after controlling for covariates, both sleep-specific rumination and sleep-specific worry showed significant concurrent and prospective associations with insomnia symptoms, and the increases in scores of sleep-specific rumination and sleep-specific worry over time were significantly associated with the increased likelihood of insomnia symptoms at follow-up. Moreover, the increases in sleep-specific rumination and sleep-specific worry over time were significantly associated with the increased likelihood of reporting newly developed insomnia symptoms rather than persistent normal sleep. However, the changes in sleep-specific rumination and sleep-specific worry were not significantly associated with the likelihood of reporting persistent or remitted insomnia symptoms rather than persistent normal sleep. In conclusion, sleep-specific rumination and sleep-specific worry were significantly associated with concurrent or subsequent insomnia symptoms; thus, they may be promising cognitive risk markers and intervention targets.
失眠症状在孕期极为普遍;因此,识别可改变的风险标志物对于风险预测和早期干预至关重要。本研究旨在探讨特定睡眠反刍和特定睡眠担忧在产前失眠症状中的作用。从中国山东两家三级综合医院的产科门诊招募了859名无精神疾病史的已婚孕妇(平均[标准差]年龄为30.15[3.86]岁;593名[69.0%]拥有本科及以上学历),她们在基线期(孕中期)和随访期(孕晚期)完成了特定睡眠反刍、特定睡眠担忧及失眠症状的评估。测量工具包括日间失眠症状反应量表、睡眠焦虑与关注问卷以及失眠严重程度指数。我们的结果显示,在控制协变量后,特定睡眠反刍和特定睡眠担忧均与失眠症状呈现显著的同时期和前瞻性关联,且特定睡眠反刍和特定睡眠担忧得分随时间的增加与随访期失眠症状发生可能性的增加显著相关。此外,特定睡眠反刍和特定睡眠担忧随时间的增加与报告新出现的失眠症状而非持续的正常睡眠的可能性增加显著相关。然而,特定睡眠反刍和特定睡眠担忧的变化与报告持续性或缓解性失眠症状而非持续正常睡眠的可能性并无显著关联。总之,特定睡眠反刍和特定睡眠担忧与同时期或后续的失眠症状显著相关;因此,它们可能是有前景的认知风险标志物和干预靶点。