Sobeeh Fatma G, Eldayem Yara B Abd, Khalifa Heba K
Lecturer of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Tanta University, El-Gash st. Medical Campus The Faculty of Medicine, Tanta, 31527, Egypt.
Assistant Professor of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Tanta University, El-Gash st. Medical Campus The Faculty of Medicine, Tanta, 31527, Egypt.
Toxicol Res (Camb). 2024 Jul 16;13(4):tfae107. doi: 10.1093/toxres/tfae107. eCollection 2024 Aug.
Organophosphate compounds (OPCs) pose significant health risks, especially in developing countries with limited resources. Predicting outcomes in OPCs poisoning is crucial for guiding clinical management and reducing mortality rates. The aim of this study to evaluate the validity of different scoring systems Rapid Emergency Medicine Score, Multiple Organ Dysfunction Score, Acute Physiology and Chronic Health Evaluation Score, and Poison Severity Score in prediction of intensive care unit (ICU) admission and mortality of acute OPCs poisoning patients.
A cross-sectional study was conducted on 103 patients admitted to Xx Poison Control Center between May 2022 and June 2023. Scoring systems were applied at admission, and their performance in predicting the need for ICU admission and mortality was evaluated using receiver operating characteristic (ROC) curve analysis.
Most patients survived (92.2%). Only 13.6% of the patients required ICU admission. Significant differences in median scores were observed between survivors and non-survivors and between patients requiring ICU admission and those who did not. Multiple Organ Dysfunction Score exhibited the highest discriminatory power for predicting both ICU admission (AUC = 0.983) and mortality (AUC = 0.999).
The findings highlight the importance of utilizing scoring systems, particularly Multiple organ dysfunction score, for prediction of poor outcomes of acute OPCs poisoning.
有机磷化合物（OPCs）带来重大健康风险，尤其是在资源有限的发展中国家。预测OPCs中毒的结果对于指导临床管理和降低死亡率至关重要。本研究的目的是评估不同评分系统（快速急诊医学评分、多器官功能障碍评分、急性生理与慢性健康评估评分和中毒严重程度评分）在预测急性OPCs中毒患者入住重症监护病房（ICU）及死亡率方面的有效性。
对2022年5月至2023年6月期间入住Xx中毒控制中心的103例患者进行了一项横断面研究。在入院时应用评分系统，并使用受试者工作特征（ROC）曲线分析评估其在预测ICU入住需求和死亡率方面的表现。
大多数患者存活（92.2%）。只有13.6%的患者需要入住ICU。在幸存者和非幸存者之间以及需要入住ICU的患者和不需要入住的患者之间观察到中位数评分存在显著差异。多器官功能障碍评分在预测ICU入住（AUC = 0.983）和死亡率（AUC = 0.999）方面表现出最高的辨别力。
研究结果突出了利用评分系统，特别是多器官功能障碍评分，来预测急性OPCs中毒不良结局的重要性。
