Fortuna Vitor, Lima Jaqueline, Oliveira Gabriel F, Oliveira Yasmin S, Getachew Bruk, Nekhai Sergei, Aschner Michael, Tizabi Yousef
Department of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, BA 40231-300, Brazil.
Postgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, BA 40231-300, Brazil.
Curr Res Toxicol. 2024 Jun 18;7:100181. doi: 10.1016/j.crtox.2024.100181. eCollection 2024.
Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.
镰状细胞病（SCD）是一种遗传性血红蛋白疾病，其特征为红细胞镰变，可导致严重贫血、疼痛发作、广泛的器官损伤和预期寿命缩短。在SCD中，铁水平升高可引发铁死亡，这是一种特定类型的细胞死亡，其特征是活性氧（ROS）和脂质过氧化物积累，导致损伤和器官功能障碍。SCD中铁、铁死亡、炎症和氧化应激之间复杂的相互作用强调了深入了解这些过程对于开发创新治疗策略的必要性。本综述强调了平衡各种因素之间复杂相互作用以及利用这些知识开发针对这种毁灭性疾病的新型疗法的重要性。
