College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P.R. China.
Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P.R. China.
J Agric Food Chem. 2023 Nov 8;71(44):16727-16738. doi: 10.1021/acs.jafc.3c04801. Epub 2023 Oct 23.
Di-(2-ethylhexyl) phthalate (DEHP) is frequently used as a plasticizer in industrial and agricultural products. DEHP can cause severe neurotoxicity, such as impaired learning and memory function. Lycopene (LYC) as a carotenoid exerts excellent antioxidant capacity and therapeutic effects in neurodegenerative diseases. However, whether LYC can prevent the cognitive impairment induced by DEHP and the specific mechanisms are unclear. In the present study, the behavioral test results suggested that LYC alleviated the learning and memory impairment induced by DEHP. The histopathological data revealed that LYC attenuated DEHP-induced disordered arrangement of the neurons in the CA1 and CA3 regions of the hippocampus tissue. Moreover, LYC inhibited the occurrence of DEHP-induced ferroptosis via regulating iron metabolism, inhibiting lipid peroxidation, and activating the cysteine transporter and nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (NrF2/HO-1) signaling pathway. Overall, the study contributes novel perspectives into the potential mechanisms of LYC preventing phthalate-induced cognitive impairment in the hippocampus.
邻苯二甲酸二（2-乙基己基）酯（DEHP）常被用作工业和农业产品中的增塑剂。DEHP 可引起严重的神经毒性，如学习和记忆功能受损。番茄红素（LYC）作为一种类胡萝卜素，在神经退行性疾病中具有优异的抗氧化能力和治疗效果。然而，LYC 是否能预防 DEHP 引起的认知障碍以及具体的机制尚不清楚。在本研究中，行为学测试结果表明 LYC 减轻了 DEHP 引起的学习和记忆障碍。组织病理学数据显示，LYC 可减轻 DEHP 诱导的海马组织 CA1 和 CA3 区神经元排列紊乱。此外，LYC 通过调节铁代谢、抑制脂质过氧化、激活半胱氨酸转运体和核因子红细胞 2 相关因子 2/血红素加氧酶-1（NrF2/HO-1）信号通路，抑制 DEHP 诱导的铁死亡的发生。总的来说，该研究为 LYC 预防海马体中邻苯二甲酸酯引起的认知障碍的潜在机制提供了新的视角。
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