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胃肠道免疫相关不良事件的组织病理学特征:1例接受免疫检查点抑制剂治疗的肺鳞状细胞癌患者发生严重急性呼吸综合征冠状病毒2和巨细胞病毒感染

Histopathologic Features of Immune-related Adverse Events in the Gastrointestinal Tract: A Case of Severe Acute Respiratory Syndrome Coronavirus 2 and Cytomegalovirus Infection in a Patient with Lung Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors.

作者信息

Hashizume Akane, Izumi Hiroshi, Tomita Shigeki, Osada Taro, Sasaki Shinichi, Yao Takashi

出版信息

Juntendo Iji Zasshi. 2022 Jul 14;68(4):393-397. doi: 10.14789/jmj.JMJ22-0004-CR. eCollection 2022.

Abstract

In this article, we report the case of a patient with unresectable stage III squamous cell lung carcinoma who developed immune-related adverse events in the gastrointestinal tract following the administration of immune checkpoint inhibitors. The patient developed severe acute respiratory syndrome coronavirus 2 pneumonia and cytomegalovirus gastritis during immunosuppressive therapy for an immune-related adverse event. Cytomegalovirus infection was managed with the administration of ganciclovir.

摘要

在本文中,我们报告了一例不可切除的III期肺鳞状细胞癌患者,该患者在使用免疫检查点抑制剂后出现了胃肠道免疫相关不良事件。该患者在针对免疫相关不良事件进行免疫抑制治疗期间发生了严重急性呼吸综合征冠状病毒2肺炎和巨细胞病毒性胃炎。通过给予更昔洛韦来处理巨细胞病毒感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab1e/11250008/349f53c470da/2188-2126-68-4-0393-g001.jpg

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