一项针对癌症患者的基于接纳与承诺疗法的灵活干预措施的混合方法可行性和可接受性研究。
A mixed method feasibility and acceptability study of a flexible intervention based on acceptance and commitment therapy for patients with cancer.
作者信息
Bourgognon François, Bechet Denise, Huin-Schohn Cécile, Strelow Aurélia, Demarche Laëtitia, Guillou Mireille, Adam Virginie, Fall Estelle, Omorou Abdou Yacoubou
机构信息
Department of Supportive Care in Oncology, Institut de Cancérologie de Lorraine, Vandæuvre-lès-Nancy, France.
Departement of Clinical Research, Institut de Cancérologie de Lorraine, Vandæuvre-lès-Nancy, France.
出版信息
Front Psychol. 2024 Jul 3;15:1409308. doi: 10.3389/fpsyg.2024.1409308. eCollection 2024.
PROPOSE
This study aimed to propose an innovative, open, and circular program that combines acceptance and commitment therapy (ACT) and mindfulness practices. We assessed its feasibility, acceptability, and first signs of its effect on psychological wellbeing in cancer support treatment.
METHODS
A single-center, single-arm, uncontrolled study was performed. Forty adult patients with non-metastatic prostate or breast cancer, newly diagnosed or undergoing treatment (chemotherapy, radiotherapy, hormone therapy), were recruited. Three cycles of three MAEva program sessions (MAEva: Mindfulness meditation, Acceptance, and Commitment to values program) over nine consecutive weeks were proposed. During the total of 12 weeks of follow-up, after attending the first session, patients were free to attend subsequent sessions.
RESULTS
Adherence to the study was high, with participation in an average of 6.8 out of nine sessions. A total of eight patients attended all sessions over the three cycles, and 90% participated in at least one cycle. Furthermore, attendance was associated with a statistically significant improvement in Quality of Life (QoL). Each additional session was associated with a mean increase in overall QoL score of more than one point (β = 1.09 [0.13; 2.04], = 0.02). The fatigue dimensions decreased with session attendance: physical (β = -2.24 [-3.63; -0.85]), emotional (β = -2.60 [-4.11; -1.09]), and interference with daily life (β = -2.33 [-3.95; -0.72]). The qualitative section demonstrated that patients learned skills and shared their ability to "let go". Patients rated the degree of importance of the program at 8.36/10 (SD ± 1.64).
CONCLUSION
This study highlights the feasibility and acceptability of an original program that combines ACT and mindfulness practices in cancer patients. Future studies are required to demonstrate the efficacy of the MAEVA program. The MAEva pilot study is registered with ClinicalTrials.gov under the identifier NCT04751201.
CLINICAL TRIAL REGISTRATION
https://classic.clinicaltrials.gov/ct2/show/NCT04751201, identifier [NCT04751201].
目的
本研究旨在提出一个创新、开放且循环的项目，该项目将接纳与承诺疗法（ACT）和正念练习相结合。我们评估了其在癌症支持治疗中对心理健康的可行性、可接受性以及初步效果迹象。
方法
开展了一项单中心、单臂、非对照研究。招募了40名新诊断或正在接受治疗（化疗、放疗、激素治疗）的非转移性前列腺癌或乳腺癌成年患者。提出了连续九周进行三个周期、每个周期包含三个MAEva项目课程（MAEva：正念冥想、接纳和价值观承诺项目）的方案。在总共12周的随访期间，患者在参加第一节课后可自由参加后续课程。
结果
研究依从性较高，平均参加了九个课程中的6.8个。共有8名患者参加了三个周期的所有课程，90%的患者至少参加了一个周期。此外，出勤率与生活质量（QoL）的统计学显著改善相关。每增加一节课，总体QoL评分平均增加超过一分（β = 1.09 [0.13; 2.04]，P = 0.02）。随着课程参与，疲劳维度有所下降：身体疲劳（β = (-2.24 [-3.63; -0.85])）、情绪疲劳（β = (-2.60 [-4.11; -1.09])）以及对日常生活的干扰（β = (-2.33 [-3.95; -0.72])）。定性部分表明患者学到了技能并分享了他们“放手”的能力。患者对该项目重要性的评分是8.36/10（标准差±1.64）。
结论
本研究突出了将ACT和正念练习相结合的原创项目在癌症患者中的可行性和可接受性。未来需要进一步研究来证明MAEVA项目的疗效。MAEva试点研究已在ClinicalTrials.gov上注册，标识符为NCT04751201。
临床试验注册
https://classic.clinicaltrials.gov/ct2/show/NCT04751201，标识符 [NCT04751201]
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