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Pentraxin-3 and neonatal sepsis: a systematic review and meta-analysis.血清淀粉样蛋白 3 与新生儿败血症：系统评价和荟萃分析。
J Matern Fetal Neonatal Med. 2023 Dec;36(1):2205986. doi: 10.1080/14767058.2023.2205986.
2
National incidence and mortality of hospitalized sepsis in China.中国住院脓毒症的发病率和死亡率。
Crit Care. 2023 Mar 4;27(1):84. doi: 10.1186/s13054-023-04385-x.
3
Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.血清淀粉样蛋白 P 作为脓毒症患者死亡率的预测标志物：一项更新的系统评价和荟萃分析。
Crit Care. 2022 Jun 8;26(1):167. doi: 10.1186/s13054-022-04032-x.
4
Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions.通过脓毒症3.0定义，血清淀粉样蛋白P成分是重症监护病房中脓毒症严重程度识别的有力生物标志物及90天死亡率的预测指标。
Diagnostics (Basel). 2021 Oct 15;11(10):1906. doi: 10.3390/diagnostics11101906.
5
Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever.急性风湿热患者中五聚体蛋白3水平及其与疾病严重程度的相关性
Arch Rheumatol. 2021 Jan 14;36(2):233-243. doi: 10.46497/ArchRheumatol.2021.8232. eCollection 2021 Jun.
6
Pathophysiology of sepsis.脓毒症的病理生理学。
Curr Opin Anaesthesiol. 2021 Apr 1;34(2):77-84. doi: 10.1097/ACO.0000000000000963.
7
A Proteomics-Based Assessment of Inflammation Signatures in Endotoxemia.基于蛋白质组学的内毒素血症炎症特征评估。
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8
The value of neutrophil gelatinase-associated lipocalin and citrullinated alpha enolase peptide-1 antibody in diagnosis, classification, and prognosis for patients with sepsis.中性粒细胞明胶酶相关脂质运载蛋白和瓜氨酸化α烯醇化酶肽-1抗体在脓毒症患者诊断、分类及预后评估中的价值
Medicine (Baltimore). 2020 Aug 21;99(34):e21893. doi: 10.1097/MD.0000000000021893.
9
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作为脓毒症生物标志物的五聚体蛋白-3（PTX-3）的研究进展

Progress in the study of pentraxin-3(PTX-3) as a biomarker for sepsis.

作者信息

Zhang Yi, Li Xuelin, Zhang Xiaobei, Wang Tiantian, Zhang Xiangcheng

机构信息

Department of Critical Care Medicine, The Affiliated Huai'an No 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.

出版信息

Front Med (Lausanne). 2024 Jul 3;11:1398024. doi: 10.3389/fmed.2024.1398024. eCollection 2024.

DOI:10.3389/fmed.2024.1398024
PMID:39021820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11251883/
Abstract

Sepsis is a intricate pathological process characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection. It stands as a prominent cause of mortality among critically ill patients globally. The pivotal focus in sepsis management lies in the early identification and prompt administration of antimicrobial agents. Owing to the constraints of current diagnostic methodologies, marked by insufficient sensitivity and delayed outcomes, extensive research has been undertaken to ascertain novel biomarkers for sepsis. In this review, we provide an overview discussing the latest advancements in the study of PTX-3 as a biomarker for sepsis. We acknowledge pivotal discoveries from preceding research and engage in discourse regarding the challenges and limitations confronted by PTX-3 as a sepsis biomarker.

摘要

脓毒症是一种复杂的病理过程，其特征是宿主对感染的反应失调导致危及生命的器官功能障碍。它是全球危重症患者死亡的主要原因。脓毒症管理的关键在于早期识别和及时使用抗菌药物。由于目前诊断方法存在灵敏度不足和结果延迟的局限性，人们进行了广泛研究以确定脓毒症的新型生物标志物。在本综述中，我们概述了作为脓毒症生物标志物的PTX-3研究的最新进展。我们认可先前研究的关键发现，并讨论PTX-3作为脓毒症生物标志物所面临的挑战和局限性。