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血清淀粉样蛋白 P 作为脓毒症患者死亡率的预测标志物：一项更新的系统评价和荟萃分析。

Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis.

机构信息

Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, Zhejiang, People's Republic of China.

出版信息

Crit Care. 2022 Jun 8;26(1):167. doi: 10.1186/s13054-022-04032-x.

DOI:10.1186/s13054-022-04032-x
PMID:35676730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9175505/
Abstract

BACKGROUND

The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis.

METHODS

Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case-control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the correlation of the outcomes with sample size and male proportion.

RESULTS

A total of 17 studies covering 3658 sepsis patients were included. PTX3 level was significantly higher in non-survivor compared to survivor patients (SMD (95% CI): -1.06 (-1.43, -0.69), P < 0.001). Increased PTX3 level was significantly associated with mortality (HR (95% CI): 2.09 (1.55, 2.81), P < 0.001). PTX3 showed good predictive capability for mortality (AUC:ES (95% CI): 0.73 (0.70, 0.77), P < 0.001). The outcome comparing PTX3 level in non-survivors vs. survivors and the outcome of the association between PTX3 and mortality were associated with sample size but not male proportion. AUC was associated with both sample size and male proportion.

CONCLUSIONS

PTX3 level was significantly higher in non-survivor compared to survivor patients with sepsis. Elevated PTX3 level was significantly associated with mortality. Furthermore, the level of PTX3 might predict patient mortality.

摘要

背景

本研究旨在阐明 Pentraxin-3（PTX3）对脓毒症患者死亡率的预后价值。

方法

从 PubMed、EMBASE 和 Cochrane 图书馆检索截至 2021 年 1 月发表的文献。对合格的队列研究和病例对照研究进行数据提取，用于荟萃分析。采用多变量回归分析评估结局与样本量和男性比例的相关性。

结果

共纳入 17 项研究，涵盖 3658 例脓毒症患者。与存活患者相比，非存活患者的 PTX3 水平显著升高（SMD（95%CI）：-1.06（-1.43，-0.69），P<0.001）。PTX3 水平升高与死亡率显著相关（HR（95%CI）：2.09（1.55，2.81），P<0.001）。PTX3 对死亡率具有良好的预测能力（AUC：ES（95%CI）：0.73（0.70，0.77），P<0.001）。比较非存活者与存活者的 PTX3 水平的结局以及 PTX3 与死亡率之间的关联结局与样本量有关，但与男性比例无关。AUC 与样本量和男性比例均有关。

结论

与存活患者相比，脓毒症非存活患者的 PTX3 水平显著升高。PTX3 水平升高与死亡率显著相关。此外，PTX3 水平可能预测患者死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/2706d66f72ea/13054_2022_4032_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/e6feb138c72d/13054_2022_4032_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/2c08b8feb42d/13054_2022_4032_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/d243dba377c1/13054_2022_4032_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/8c163ffe8f15/13054_2022_4032_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/f4257781c8c0/13054_2022_4032_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/2706d66f72ea/13054_2022_4032_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/e6feb138c72d/13054_2022_4032_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/502e655b3226/13054_2022_4032_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/9840d97bce75/13054_2022_4032_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/8a6c8a980ae8/13054_2022_4032_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/2c08b8feb42d/13054_2022_4032_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/d243dba377c1/13054_2022_4032_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/8c163ffe8f15/13054_2022_4032_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/f4257781c8c0/13054_2022_4032_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7857/9175505/2706d66f72ea/13054_2022_4032_Fig9_HTML.jpg

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