Herr Rachel, Grewal Himmat, Abdelghani Ramsy
Division of Pulmonary and Critical Care at Tulane University School of Medicine, New Orleans, LA, USA.
Respir Med Case Rep. 2024 Jun 5;50:102059. doi: 10.1016/j.rmcr.2024.102059. eCollection 2024.
Spindle cell lesions span from benign to aggressively malignant, the most concerning being the carcinoma, sarcoma, and melanoma species. While spindle cell carcinoma is the most common spindle cell lesion found along the upper aerodigestive tract (UADT), it only accounts for <0.5 % of pulmonary malignancies [1,2]. We present an adult male admitted for chest pain, who was found to have a malignant left upper lobe (LUL) spindle cell neoplasm. Three pathology departments preformed immunohistochemical analysis on various tissue specimens, searching for a speciated diagnosis, highlighting the importance of advanced immunostains for the diagnosis and subsequent treatment of these difficult lesions.
梭形细胞病变涵盖从良性到侵袭性恶性的范围，最令人担忧的是癌、肉瘤和黑色素瘤类型。虽然梭形细胞癌是在上呼吸道消化道（UADT）发现的最常见的梭形细胞病变，但它仅占肺恶性肿瘤的不到0.5%[1,2]。我们报告一名因胸痛入院的成年男性，他被发现患有左肺上叶（LUL）恶性梭形细胞瘤。三个病理科对各种组织标本进行了免疫组织化学分析，以寻求明确诊断，突出了先进免疫染色对这些疑难病变诊断及后续治疗的重要性。
