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来自红肉火龙果的甜菜色素对甲型流感病毒表现出抗病毒反应。

Betacyanins from red pitahaya () exhibit antiviral response against influenza A virus.

作者信息

Lim Chie Min, Lal Sunil Kumar, Isa Nurulfiza Mat, Omar Abdul Rahman, Choo Wee Sim

机构信息

School of Science, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.

Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, 43400, UPM, Selangor, Malaysia.

出版信息

Heliyon. 2024 Jun 15;10(12):e33049. doi: 10.1016/j.heliyon.2024.e33049. eCollection 2024 Jun 30.

DOI:10.1016/j.heliyon.2024.e33049
PMID:39021953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11252771/
Abstract

Seasonal influenza affects millions of lives worldwide, with the influenza A virus (IAV) responsible for pandemics and annual epidemics, causing the most severe illnesses resulting in patient hospitalizations or death. With IAV threatening the next global influenza pandemic, it is a race against time to search for antiviral drugs. Betacyanins are unique nitrogen-containing and water-soluble reddish-violet pigments that have been reported to possess antiviral properties against the dengue virus. This study aimed to examine the antiviral effect of betacyanins from red pitahaya () on IAV-infected lung epithelial A549 cells. HPLC and LC-MS analysis of extracted betacyanin showed four betacyanins in the betacyanin fraction: phyllocactin, hylocerenin, betanin, and isobetanin. Cytotoxicity assay showed that betacyanin fractions were not cytotoxic to A549 cells at concentrations below 100 μg/mL. Betacyanin fraction concentrations of 12.5, 25.0, and 50.0 μg/mL prevented the formation of viral cytopathic effect and reduced virus titer in IAV-infected cells up to 72 h. A downregulation of protein and mRNA nucleoprotein expression levels was observed after treatment with 25.0 and 50.0 μg/mL of betacyanin fraction after 24 h, thereby providing evidence for the antiviral activity of betacyanin from red pitahaya against IAV .

摘要

季节性流感影响着全球数百万人的生活，甲型流感病毒（IAV）引发大流行和年度疫情，导致最严重的疾病，造成患者住院或死亡。由于IAV威胁着下一次全球流感大流行，寻找抗病毒药物刻不容缓。甜菜色素是一类独特的含氮水溶性红紫色色素，据报道具有抗登革病毒的特性。本研究旨在探讨红心火龙果中甜菜色素对IAV感染的肺上皮A549细胞的抗病毒作用。对提取的甜菜色素进行HPLC和LC-MS分析，结果显示甜菜色素组分中有四种甜菜色素：叶仙人掌素、仙人掌黄素、甜菜红素和异甜菜红素。细胞毒性试验表明，在浓度低于100μg/mL时，甜菜色素组分对A549细胞无细胞毒性。12.5、25.0和50.0μg/mL的甜菜色素组分浓度可防止病毒致细胞病变效应的形成，并在长达72小时内降低IAV感染细胞中的病毒滴度。在24小时后用25.0和50.0μg/mL的甜菜色素组分处理后，观察到蛋白质和mRNA核蛋白表达水平下调，从而为红心火龙果中的甜菜色素对IAV的抗病毒活性提供了证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/14c0f1216b4e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/bbb6e8884318/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/a558a3249b94/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/d938525bd1e2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/aecd9be1f5fd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/612958d72349/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/bfb4d6baf87c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/14c0f1216b4e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/bbb6e8884318/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/a558a3249b94/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/d938525bd1e2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/aecd9be1f5fd/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/612958d72349/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/bfb4d6baf87c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c16/11252771/14c0f1216b4e/gr7.jpg

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