Zhao Bingqing, Jia Weihua, Yuan Ye, Chen Ying, Gao Yali, Yang Baoling, Zhao Wei, Wu Jingyi
Department of Neurology, Beijing Shijingshan Hospital Capital Medical University Shjingshan Teaching Hospital, China.
University of Glasgow, United kingdom.
Heliyon. 2024 Jun 19;10(12):e33264. doi: 10.1016/j.heliyon.2024.e33264. eCollection 2024 Jun 30.
Abnormal blood pressure pattern is an independent risk factor for vascular events. Blood pressure variability can predict cardiovascular and cerebrovascular disease outcomes and is closely associated with the risk of cognitive impairment. However, the relationship between blood pressure variability and cerebral small vessel disease neuroimaging markers remains unclear. This study aimed to evaluate the relationship between blood pressure variability and cerebral small vessel disease neuroimaging markers.
We searched multiple databases, including Embase, Web of Science, PubMed, Cochrane Library, UpToDate, and World of Science, from their inception until November 27, 2023.Main Outcomes and Measures: A meta-analysis of 19 observational studies involving 14519 participants was performed. Findings: ①Systolic blood pressure variability was correlated with the cerebral small vessel disease total burden, white matter hyperintensities and lacunar infarction; ② Diastolic blood pressure variability was correlated with the cerebral small vessel disease total burden, white matter hyperintensities and cerebral microbleeds; ③ Non-dipping patterns were correlated with white matter hyperintensities and lacunar infarction. ④ Reverse-dipping patterns were significantly correlated with white matter hyperintensities and cerebral microbleeds.
and Relevance: Blood pressure variability correlates with neuroimaging markers of cerebral small vessel disease and its burden. Hence, early monitoring and intervention of blood pressure variability may be essential for the early diagnosis, prevention and treatment of cerebral small vessel disease.
异常血压模式是血管事件的独立危险因素。血压变异性可预测心血管和脑血管疾病的预后，且与认知障碍风险密切相关。然而，血压变异性与脑小血管病神经影像学标志物之间的关系仍不明确。本研究旨在评估血压变异性与脑小血管病神经影像学标志物之间的关系。
我们检索了多个数据库，包括Embase、Web of Science、PubMed、Cochrane图书馆、UpToDate和科学世界，检索时间从各数据库创建至2023年11月27日。
对19项涉及14519名参与者的观察性研究进行了荟萃分析。
①收缩压变异性与脑小血管病总负担、白质高信号和腔隙性梗死相关；②舒张压变异性与脑小血管病总负担、白质高信号和脑微出血相关；③非勺型模式与白质高信号和腔隙性梗死相关；④反勺型模式与白质高信号和脑微出血显著相关。
血压变异性与脑小血管病的神经影像学标志物及其负担相关。因此，对血压变异性进行早期监测和干预可能对脑小血管病的早期诊断、预防和治疗至关重要。
