Luo Chenxi, Zhang Wei, Zhu Jicheng, Qiu Tianlai, Fang Qingbo
School of Public Health, Wuhan University, Wuhan, 430071, China.
School of Nursing, Wuhan University, Wuhan, 430071, China.
Heliyon. 2024 Jun 17;10(12):e33194. doi: 10.1016/j.heliyon.2024.e33194. eCollection 2024 Jun 30.
The relationship between the gut microbiota and acute myeloid leukemia (AML) has been established, but the exact role of interleukin (IL) in mediating this relationship has remained unclear. This study aimed to utilize whether interleukins mediate the relationships between gut microbiota and AML, thereby identifying potential novel targets for future AML treatment. Mendelian randomization (MR) is a method for finding the causality of exposure and outcome. Final instrumental variables were selected based on MR assumptions, and used to judge validity of the results. Our study identified risk and protective factors for AML, and interleukin-related gut microbiota. Finally, mediation MR analyses resulted in Interleukin-2 (IL-2) mediated associations between , and AML, with IL-2 respectively explaining 13.96 % and 12.11 % of the total effect of the aforementioned gut microbiota on AML. Our results successfully identified causal effects between specific gut microbiota, AML, and interleukins, while also elucidating the mediating role of IL-2 in these associations using MR analysis. These findings provide valuable insights into potential therapeutic targets for AML treatment.
肠道微生物群与急性髓系白血病（AML）之间的关系已经确立，但白细胞介素（IL）在介导这种关系中的确切作用仍不清楚。本研究旨在探讨白细胞介素是否介导肠道微生物群与AML之间的关系，从而确定未来AML治疗的潜在新靶点。孟德尔随机化（MR）是一种用于发现暴露与结局因果关系的方法。基于MR假设选择最终的工具变量，并用于判断结果的有效性。我们的研究确定了AML的风险和保护因素，以及与白细胞介素相关的肠道微生物群。最后，中介MR分析得出白细胞介素-2（IL-2）介导了[此处原文缺失部分内容]与AML之间的关联，IL-2分别解释了上述肠道微生物群对AML总效应的13.96%和12.11%。我们的结果成功确定了特定肠道微生物群、AML和白细胞介素之间的因果效应，同时还使用MR分析阐明了IL-2在这些关联中的中介作用。这些发现为AML治疗的潜在治疗靶点提供了有价值的见解。
