Wethington J F
Clin Ther. 1985;7(5):641-6.
Forty-four patients with sore throat participated in a placebo-controlled, double-blind clinical trial of benzydamine hydrochloride administered as a gargle. After medical evaluation and throat culture, 21 patients were treated with a solution containing benzydamine and 23 patients with a placebo solution. Statistical analysis of scores from patients' diaries showed that benzydamine solution afforded significantly greater (P less than 0.001) relief of pain and dysphagia at 24 hours than did the placebo solution. Physician evaluations at 24 hours showed that the benzydamine solution had significantly greater effect than did placebo on hyperemia (P less than 0.004) and edema (P less than 0.005). Side effects were minimal and of no clinical significance. The findings indicate that benzydamine hydrochloride is safe and effective therapy for the signs and symptoms of sore throat.
44名咽喉疼痛患者参与了一项将盐酸苄达明用作漱口水的安慰剂对照双盲临床试验。经过医学评估和咽喉培养后，21名患者接受含苄达明的溶液治疗，23名患者接受安慰剂溶液治疗。对患者日记评分的统计分析表明，苄达明溶液在24小时时缓解疼痛和吞咽困难的效果明显优于安慰剂溶液（P小于0.001）。24小时时医生的评估表明，苄达明溶液在治疗充血（P小于0.004）和水肿（P小于0.005）方面比安慰剂有明显更好的效果。副作用极小且无临床意义。研究结果表明，盐酸苄达明是治疗咽喉疼痛体征和症状的安全有效疗法。
