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埃塞俄比亚 12-23 月龄儿童中肺炎球菌疫苗接种脱落的决定因素:2019 年小型人口与健康调查的二次分析。

Determinants of pneumococcal vaccination dropout among children aged 12-23 months in Ethiopia: a secondary analysis from the 2019 mini demographic and health survey.

机构信息

Unit of Immunology, Department of Medical Laboratory Science, Debre Tabor University, Debre Tabor, Ethiopia.

Unit of Medical Microbiology, Department of Medical Laboratory Science, Debre Tabor University, Debre Tabor, Ethiopia.

出版信息

Front Public Health. 2024 Jul 3;12:1362900. doi: 10.3389/fpubh.2024.1362900. eCollection 2024.

Abstract

BACKGROUND

Vaccination is a cost-effective public health program that helps reduce significant morbidity and mortality in children under the age of five. Worldwide, the number of vaccine-preventable causes of child death has significantly decreased since the Expanded Program of Immunization (EPI) was introduced. However, for a variety of reasons, 23 million children did not have adequate access to vaccines in 2020. Therefore, this study aimed to evaluate the determinants of pneumonia conjugate vaccine (PCV) dropout among children aged 12-23 months in Ethiopia.

METHODS

The study analyzed cross-sectional data obtained from the 2019 mini Ethiopian demographic and health survey. Multilevel binary logistic regression analysis was utilized, and the best fit model was chosen using the Akaike Information Criteria. The study comprised a weighted sample of 989 children aged 12 to 23 months. The study presented the Adjusted Odds Ratio (AOR) along with a 95% Confidence Interval (CI) to identify the significant factors influencing PCV dropout.

RESULTS

The PCV dropout rate was reported at 20.2% in this study. In the multilevel analysis, possession of a health card (AOR = 0.076, 95% CI: 0.019, 0.04), vaccination for PCV 2 (AOR =0.002, 95% CI: 0.023, 0.263), and region 7 (AOR = 6.98, 95% CI: 10.1, 48.31) were significantly associated with children's PCV dropout.

CONCLUSION

Having a health card, having received the PCV 2 vaccinations, and region were significant predictors of PCV dropout. Consequently, health education on immunization for all mothers and region-specific, customized public health interventions are needed to reduce the vaccination dropout rate.

摘要

背景

接种疫苗是一项具有成本效益的公共卫生计划,有助于降低 5 岁以下儿童的发病率和死亡率。自扩大免疫规划(EPI)推出以来,全球范围内可通过疫苗预防的儿童死亡原因数量显著减少。然而,由于各种原因,2020 年仍有 2300 万儿童无法充分获得疫苗。因此,本研究旨在评估埃塞俄比亚 12-23 个月儿童肺炎球菌结合疫苗(PCV)脱落的决定因素。

方法

本研究分析了来自 2019 年迷你埃塞俄比亚人口和健康调查的横断面数据。采用多水平二项逻辑回归分析,使用赤池信息量准则选择最佳拟合模型。研究包含了一个加权样本,其中有 989 名 12 至 23 个月大的儿童。研究报告了调整后的优势比(AOR)及其 95%置信区间(CI),以确定影响 PCV 脱落的显著因素。

结果

本研究报告的 PCV 脱落率为 20.2%。在多水平分析中,拥有健康卡(AOR=0.076,95%CI:0.019,0.04)、接种 PCV 2 疫苗(AOR=0.002,95%CI:0.023,0.263)和第 7 区(AOR=6.98,95%CI:10.1,48.31)与儿童 PCV 脱落显著相关。

结论

拥有健康卡、接种过 PCV 2 疫苗和所在地区是 PCV 脱落的显著预测因素。因此,需要针对所有母亲开展免疫接种健康教育,并实施针对特定地区的、定制化的公共卫生干预措施,以降低疫苗接种脱落率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea9/11251995/eeaee9661eb4/fpubh-12-1362900-g001.jpg

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