Marone P, Concia E, Maserati R, Suter F, Minoli L, Andreoni M, Fiori G
Chemioterapia. 1985 Aug;4(4):289-92.
In this study we report about the efficacy and tolerability of ceftazidime in the treatment of 10 cases of pseudomonal meningitis (nine Pseudomonas aeruginosa and one Pseudomonas cepacia). The 10 patients had a pseudomonal infection of the central nervous system (CNS) complicating neurosurgical procedures or developed on a preexisting immunodepressing condition; four patients were of pediatric age. All isolates were sensitive to ceftazidime with MICs ranging from 0.39 to 3.12 micrograms/ml. Ceftazidime was given intravenously at the dosage of 100-150 mg/kg/day. In seven cases amikacin was associated by intralumbar or intraventricular instillation. The duration of ceftazidime treatment ranged from 9 to 49 days with a mean of 22.2. Eight cases out of ten were cured bacteriologically and clinically, while the remaining two were cured after treatment with other antibiotics. Concentrations of ceftazidime in serum and in lumbar and/or ventricular cerebrospinal fluid (CSF) were obtained in four cases; the mean concentration in lumbar CSF was 12.2 micrograms/ml and in ventricular 3.3 micrograms/ml. The study demonstrated that ceftazidime is effective in the treatment of Pseudomonal meningitis.
在本研究中，我们报告了头孢他啶治疗10例假单胞菌性脑膜炎（9例铜绿假单胞菌和1例洋葱伯克霍尔德菌）的疗效和耐受性。这10例患者患有中枢神经系统（CNS）假单胞菌感染，这是神经外科手术的并发症，或在先前存在的免疫抑制状态下发生；4例为儿童患者。所有分离株对头孢他啶敏感，MIC范围为0.39至3.12微克/毫升。头孢他啶以100 - 150毫克/千克/天的剂量静脉给药。7例患者联合使用阿米卡星进行腰椎或脑室内注射。头孢他啶治疗持续时间为9至49天，平均为22.2天。10例中有8例在细菌学和临床上治愈，其余2例在使用其他抗生素治疗后治愈。4例患者测定了血清、腰椎和/或脑室脑脊液（CSF）中头孢他啶的浓度；腰椎CSF中的平均浓度为12.2微克/毫升，脑室中的平均浓度为3.3微克/毫升。该研究表明头孢他啶治疗假单胞菌性脑膜炎有效。
