Rodriguez W J, Khan W N, Cocchetto D M, Feris J, Puig J R, Akram S
Children's Hospital National Medical Center, Washington, DC 20010.
Pediatr Infect Dis J. 1990 Feb;9(2):83-7. doi: 10.1097/00006454-199002000-00004.
In ongoing studies in Europe and the United States, 10 pediatric patients with bacterial meningitis caused by Pseudomonas species were treated with ceftazidime. Pseudomonas aeruginosa was isolated from the CSF of 7 patients and other Pseudomonas species from the remaining 3. Eight of the 10 patients had received previous antimicrobial treatment which included aminoglycosides in 6, along with ticarcillin and ureidopenicillins in 3. Ceftazidime was administered 10 to 42 days in dosages ranging from 109 to 300 mg/kg/day. Seven of the 10 patients received ceftazidime only for 10 to 42 days. The other 3 patients received amikacin in 2 and gentamicin and tobramycin in the other. Seven patients were cured clinically and 3 died; 9 were cured bacteriologically and one who was presumed cured on the basis of clinical response subsequently died. Sterilization of the cerebrospinal fluid occurred at 48 hours to 12 days. Ceftazidime appears useful in treating bacterial meningitis caused by Pseudomonas species.
在欧洲和美国正在进行的研究中，10例由假单胞菌属引起细菌性脑膜炎的儿科患者接受了头孢他啶治疗。7例患者的脑脊液中分离出铜绿假单胞菌，其余3例分离出其他假单胞菌属。10例患者中有8例曾接受过抗菌治疗，其中6例使用过氨基糖苷类药物，3例同时使用过替卡西林和脲基青霉素。头孢他啶给药10至42天，剂量为109至300mg/kg/天。10例患者中有7例仅接受了10至42天的头孢他啶治疗。另外3例患者中，2例接受了阿米卡星治疗，另1例接受了庆大霉素和妥布霉素治疗。7例患者临床治愈，3例死亡；9例细菌学治愈，1例根据临床反应推测已治愈，但随后死亡。脑脊液灭菌发生在48小时至12天。头孢他啶似乎对治疗由假单胞菌属引起的细菌性脑膜炎有用。
