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Reply to: Challenges to identifying risk versus protective factors in Alzheimer's disease.

作者信息

Fortea Juan, Vaqué-Alcázar Lídia, Pegueroles Jordi, Alcolea Daniel, Belbin Olivia, Dols-Icardo Oriol, Videla Laura, Gispert Juan Domingo, Suárez-Calvet Marc, Johnson Sterling C, Sperling Reisa, Bejanin Alexandre, Lleó Alberto, Montal Víctor

机构信息

Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau, Barcelona, Spain.

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

出版信息

Nat Med. 2024 Nov;30(11):3096-3097. doi: 10.1038/s41591-024-03159-4. Epub 2024 Jul 18.

DOI:10.1038/s41591-024-03159-4
PMID:39025967
Abstract
摘要

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本文引用的文献

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Nat Med. 2024 May;30(5):1284-1291. doi: 10.1038/s41591-024-02931-w. Epub 2024 May 6.
2
Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults.他汀类药物的起始治疗与遗传易感老年人群中阿尔茨海默病和认知能力下降的发生风险。
Neurology. 2024 Apr 9;102(7):e209168. doi: 10.1212/WNL.0000000000209168. Epub 2024 Mar 6.
3
Reduced penetrance of gene variants causing amyotrophic lateral sclerosis.
Analysis of Cerebrospinal Fluid, Plasma β-Amyloid Biomarkers, and Cognition from a 2-Year Phase 2 Trial Evaluating Oral ALZ-801/Valiltramiprosate in APOE4 Carriers with Early Alzheimer's Disease Using Quantitative Systems Pharmacology Model.
分析来自一项为期 2 年的 2 期临床试验的数据，该试验评估了口服 ALZ-801/Valiltramiprosate 在携带 APOE4 的早期阿尔茨海默病患者中的疗效，该试验使用了定量系统药理学模型，评估了脑脊液、血浆 β-淀粉样蛋白生物标志物和认知功能。
Drugs. 2024 Jul;84(7):825-839. doi: 10.1007/s40265-024-02068-7. Epub 2024 Jun 20.
导致肌萎缩侧索硬化症的基因突变外显率降低。
J Med Genet. 2024 Feb 21;61(3):294-297. doi: 10.1136/jmg-2023-109580.
4
Lecanemab: Appropriate Use Recommendations.仑卡奈单抗：合理使用建议。
J Prev Alzheimers Dis. 2023;10(3):362-377. doi: 10.14283/jpad.2023.30.
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Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts.不完全显性与可变表达：从临床研究到人群队列
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Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.