回复：阿尔茨海默病中识别风险因素与保护因素面临的挑战 - Suppr

Reply to: Challenges to identifying risk versus protective factors in Alzheimer's disease.

作者信息

Fortea Juan, Vaqué-Alcázar Lídia, Pegueroles Jordi, Alcolea Daniel, Belbin Olivia, Dols-Icardo Oriol, Videla Laura, Gispert Juan Domingo, Suárez-Calvet Marc, Johnson Sterling C, Sperling Reisa, Bejanin Alexandre, Lleó Alberto, Montal Víctor

机构信息

Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - Biomedical Research Institute Sant Pau, Barcelona, Spain.

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

出版信息

Nat Med. 2024 Nov;30(11):3096-3097. doi: 10.1038/s41591-024-03159-4. Epub 2024 Jul 18.

DOI:10.1038/s41591-024-03159-4

PMID:39025967

Abstract

摘要

相似文献

Reply to: Challenges to identifying risk versus protective factors in Alzheimer's disease.回复：阿尔茨海默病中识别风险因素与保护因素面临的挑战

Nat Med. 2024 Nov;30(11):3096-3097. doi: 10.1038/s41591-024-03159-4. Epub 2024 Jul 18.

Galantamine for dementia due to Alzheimer's disease and mild cognitive impairment.加兰他敏治疗阿尔茨海默病所致痴呆和轻度认知障碍。

Cochrane Database Syst Rev. 2024 Nov 5;11(11):CD001747. doi: 10.1002/14651858.CD001747.pub4.

Absolute Winding Number Differentiates Mouse Spatial Navigation Strategies With Genetic Risk for Alzheimer's Disease.绝对缠绕数可区分具有阿尔茨海默病遗传风险的小鼠空间导航策略。

Front Neurosci. 2022 Jun 17;16:848654. doi: 10.3389/fnins.2022.848654. eCollection 2022.

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome.作为基因和连接组的函数，对阿尔茨海默病tau蛋白病的选择性易损性和恢复力。

Brain. 2025 Jul 9. doi: 10.1093/brain/awaf179.

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study.唐氏综合征与常染色体显性阿尔茨海默病患者淀粉样蛋白负担的比较：一项横断面研究。

Lancet Neurol. 2023 Jan;22(1):55-65. doi: 10.1016/S1474-4422(22)00408-2.

NIH state-of-the-science conference statement: Preventing Alzheimer's disease and cognitive decline.美国国立卫生研究院科学现状会议声明：预防阿尔茨海默病和认知衰退

NIH Consens State Sci Statements. 2010 Apr 28;27(4):1-30.

Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review.阿尔茨海默病与癌症之间的负相关关系以及导致阿尔茨海默病的其他因素：一项系统综述

BMC Neurol. 2016 Nov 22;16(1):236. doi: 10.1186/s12883-016-0765-2.

Developing biobanking processes for Alzheimer's disease and related dementia research in Africa: Experience from the Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP).为非洲阿尔茨海默病及相关痴呆症研究开发生物样本库流程：阿尔茨海默病测序项目中阿尔茨海默病多样性招募与保留研究（READD-ADSP）的经验。

Alzheimers Dement. 2025 Aug;21(8):e70559. doi: 10.1002/alz.70559.

Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis.追踪阿尔茨海默病中的炎性小体：文献计量分析的见解

Front Neurol. 2025 Jun 5;16:1540083. doi: 10.3389/fneur.2025.1540083. eCollection 2025.

Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease.CLARITY AD：早期阿尔茨海默病中lecanemab的III期试验亚洲区域分析

J Prev Alzheimers Dis. 2025 May;12(5):100160. doi: 10.1016/j.tjpad.2025.100160. Epub 2025 Apr 5.

引用本文的文献

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer's disease following early social isolation.在早期社会隔离后的阿尔茨海默病小鼠模型中，Arhgef7作为丰富环境挽救空间认知缺陷和焦虑样行为的关键靶点。

Alzheimers Res Ther. 2025 Jul 1;17(1):143. doi: 10.1186/s13195-025-01797-5.

APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease.APOEε4在前驱性阿尔茨海默病患者的额叶皮质白质中改变载脂蛋白E（ApoE）和脂肪酸结合蛋白7（Fabp7）。

J Neuroinflammation. 2025 Jan 30;22(1):25. doi: 10.1186/s12974-025-03349-y.

Analysis of Cerebrospinal Fluid, Plasma β-Amyloid Biomarkers, and Cognition from a 2-Year Phase 2 Trial Evaluating Oral ALZ-801/Valiltramiprosate in APOE4 Carriers with Early Alzheimer's Disease Using Quantitative Systems Pharmacology Model.分析来自一项为期 2 年的 2 期临床试验的数据，该试验评估了口服 ALZ-801/Valiltramiprosate 在携带 APOE4 的早期阿尔茨海默病患者中的疗效，该试验使用了定量系统药理学模型，评估了脑脊液、血浆 β-淀粉样蛋白生物标志物和认知功能。

Drugs. 2024 Jul;84(7):825-839. doi: 10.1007/s40265-024-02068-7. Epub 2024 Jun 20.

本文引用的文献

APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease.载脂蛋白 E4 纯合子代表一种独特的阿尔茨海默病遗传形式。

Nat Med. 2024 May;30(5):1284-1291. doi: 10.1038/s41591-024-02931-w. Epub 2024 May 6.

Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults.他汀类药物的起始治疗与遗传易感老年人群中阿尔茨海默病和认知能力下降的发生风险。

Neurology. 2024 Apr 9;102(7):e209168. doi: 10.1212/WNL.0000000000209168. Epub 2024 Mar 6.

Reduced penetrance of gene variants causing amyotrophic lateral sclerosis.导致肌萎缩侧索硬化症的基因突变外显率降低。

J Med Genet. 2024 Feb 21;61(3):294-297. doi: 10.1136/jmg-2023-109580.

Lecanemab: Appropriate Use Recommendations.仑卡奈单抗：合理使用建议。

J Prev Alzheimers Dis. 2023;10(3):362-377. doi: 10.14283/jpad.2023.30.

Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts.不完全显性与可变表达：从临床研究到人群队列

Front Genet. 2022 Jul 25;13:920390. doi: 10.3389/fgene.2022.920390. eCollection 2022.

Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts.多方法研究三个队列中影响淀粉样蛋白发病和损伤的因素。

Brain. 2022 Nov 21;145(11):4065-4079. doi: 10.1093/brain/awac213.

Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome.阿尔茨海默病与唐氏综合征患者预期寿命的关联。

JAMA Netw Open. 2022 May 2;5(5):e2212910. doi: 10.1001/jamanetworkopen.2022.12910.

Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: hazard ratios and absolute risk.淀粉样蛋白正电子发射断层扫描、性别、载脂蛋白E与无痴呆个体发生痴呆和死亡的长期关联：风险比和绝对风险

Brain Commun. 2022 Feb 2;4(2):fcac017. doi: 10.1093/braincomms/fcac017. eCollection 2022.

Alzheimer's disease associated with Down syndrome: a genetic form of dementia.唐氏综合征相关的阿尔茨海默病：一种遗传性痴呆。

Lancet Neurol. 2021 Nov;20(11):930-942. doi: 10.1016/S1474-4422(21)00245-3.

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.载脂蛋白 E3 基督城纯合子对常染色体显性阿尔茨海默病的抗性：一例报告。

Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.

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Reply to: Challenges to identifying risk versus protective factors in Alzheimer's disease.

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