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追踪阿尔茨海默病中的炎性小体：文献计量分析的见解

Tracing inflammasomes in Alzheimer's: insights from bibliometric analysis.

作者信息

Chen Yingjun, Pei Hui, Li Hao, Zeng Wenjun, Li Zhitao

机构信息

Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Front Neurol. 2025 Jun 5;16:1540083. doi: 10.3389/fneur.2025.1540083. eCollection 2025.

DOI:10.3389/fneur.2025.1540083
PMID:40538660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12176572/
Abstract

BACKGROUND

Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. The inflammasome is the core of the inflammatory response and plays an important role in the inflammatory response. Currently, ample evidence has shown that inflammasomes are closely related to the occurrence and development of Alzheimer's disease.

OBJECTIVE

To explore the evolution and development trends of inflammasomes in Alzheimer's disease using bibliometric and knowledge mapping analysis. By identifying research hotspots and emerging topics, we aim to provide new insights and directions for researchers in this field.

METHODS

All data related to inflammasomes in Alzheimer's disease from 2000 to 2024 were collected from the Web of Science Core Collection (WoSCC), and annual publications, national publication trends, and proportion charts were analyzed and plotted using GraphPad price v8.0.2. Additionally, CiteSpace (6.2.4R (64-bit) Advanced Edition), and VOSviewer (version 1.6.18) were used to analyze and visualize these data.

RESULTS

A total of 1,128 publications related to the inflammasome in Alzheimer's disease were recorded in the WoSCC, comprising 738 articles and 390 reviews. The literature was mainly from 68 countries/regions and 1,545 institutions, particularly China ( = 464) and the USA ( = 266). Despite China's leading in publication quantity, the United States holds a prominent position in the field due to the higher quality of its scholarly articles. The institution that contributes the most publications is the Helmholtz Association. JOURNAL OF MOLECULAR SCIENCES was a prolific contributor, and Nature was the most frequently cited journal. Keyword analysis showed that nlrp3 inflammasome, neuroinflammation, microglia activation, and amyloid-beta were the most common terms, reflecting the main research interests in currently published papers in this field. Research in this field primarily focuses on the NLRP3 inflammasome, which is closely associated with pathological products like Aβ and tau proteins. It can induce pyroptosis and accelerate the progression of Alzheimer's disease.

CONCLUSION

The NLRP3 inflammasome is critical in Alzheimer's disease (AD) pathogenesis. However, the peak of related literature was in 2023, suggesting a potential decline in this research hotspot. There is an urgent need to explore new pathogenic mechanisms for AD. Clearly, this is an important direction that requires deep thinking and breakthroughs.

摘要

背景

阿尔茨海默病是一种常见的痴呆类型。大量研究表明阿尔茨海默病与炎症之间存在关联。炎性小体是炎症反应的核心，在炎症反应中起重要作用。目前，大量证据表明炎性小体与阿尔茨海默病的发生和发展密切相关。

目的

利用文献计量学和知识图谱分析探讨阿尔茨海默病中炎性小体的演变和发展趋势。通过识别研究热点和新兴主题，我们旨在为该领域的研究人员提供新的见解和方向。

方法

从科学网核心合集（WoSCC）收集2000年至2024年所有与阿尔茨海默病中炎性小体相关的数据，并使用GraphPad Prism v8.0.2分析和绘制年度出版物、国家出版趋势和比例图。此外，使用CiteSpace（6.2.4R（64位）高级版）和VOSviewer（1.6.18版）对这些数据进行分析和可视化。

结果

WoSCC中总共记录了1128篇与阿尔茨海默病中炎性小体相关的出版物，包括738篇文章和390篇综述。文献主要来自68个国家/地区和1545个机构，特别是中国（=464）和美国（=266）。尽管中国在出版物数量上领先，但由于其学术文章质量较高，美国在该领域占据突出地位。发表文章最多的机构是亥姆霍兹协会。《分子科学杂志》是多产的贡献者，《自然》是被引用最频繁的期刊。关键词分析表明，NLRP3炎性小体、神经炎症微胶质细胞活化和淀粉样β蛋白是最常见术语，反映了该领域当前发表论文的主要研究兴趣。该领域的研究主要集中在NLRP3炎性小体，它与Aβ和tau蛋白等病理产物密切相关。它可诱导细胞焦亡并加速阿尔茨海默病的进展。

结论

NLRP3炎性小体在阿尔茨海默病（AD）发病机制中至关重要。然而，相关文献的峰值出现在2023年，表明这一研究热点可能会下降。迫切需要探索AD的新致病机制。显然，这是一个需要深入思考和突破的重要方向。

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